ID   K7EJS8_HUMAN            Unreviewed;       673 AA.
AC   K7EJS8;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Kin of IRRE-like protein 2 {ECO:0000313|Ensembl:ENSP00000465305};
GN   Name=KIRREL2 {ECO:0000313|Ensembl:ENSP00000465305};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465305, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465305, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465305}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC002133; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AD000864; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877729; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016882837.1; XM_017027348.1.
DR   UniGene; Hs.145729; -.
DR   ProteinModelPortal; K7EJS8; -.
DR   PRIDE; K7EJS8; -.
DR   Ensembl; ENST00000592409; ENSP00000465305; ENSG00000126259.
DR   GeneID; 84063; -.
DR   UCSC; uc060xjz.1; human.
DR   CTD; 84063; -.
DR   EuPathDB; HostDB:ENSG00000126259.19; -.
DR   HGNC; HGNC:18816; KIRREL2.
DR   OpenTargets; ENSG00000126259; -.
DR   GeneTree; ENSGT00940000160603; -.
DR   OrthoDB; 269917at2759; -.
DR   ChiTaRS; KIRREL2; human.
DR   GenomeRNAi; 84063; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000126259; Expressed in 66 organ(s), highest expression level in body of pancreas.
DR   ExpressionAtlas; K7EJS8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR013162; CD80_C2-set.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF08205; C2-set_2; 1.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 5.
DR   SMART; SM00408; IGc2; 3.
DR   SUPFAM; SSF48726; SSF48726; 5.
DR   PROSITE; PS50835; IG_LIKE; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00504776};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS01086444};
KW   Membrane {ECO:0000256|SAAS:SAAS00555568};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00289622};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00555568};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00555568}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    673       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003904103.
FT   DOMAIN       24    118       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      123    222       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      227    307       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      312    394       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      398    509       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   673 AA;  71430 MW;  9F13E368DFCEC792 CRC64;
     MLRMRVPALL VLLFCFRGRA GPSPHFLQQP EDLVVLLGEE ARLPCALGAY WGLVQWTKSG
     LALGGQRDLP GWSRYWISGN AANGQHDLHI RPVELEDEAS YECQATQAGL RSRPAQLHVL
     VPPEAPQVLG GPSVSLVAGV PANLTCRSRG DARPTPELLW FRDGVLLDGA TFHQTLLKEG
     TPGSVESTLT LTPFSHDDGA TFVCRARSQA LPTGRDTAIT LSLQYPPEVT LSASPHTVQE
     GEKVIFLCQA TAQPPVTGYR WAKGGSPVLG ARGPRLEVVA DASFLTEPVS CEVSNAVGSA
     NRSTALDVLF GPILQAKPEP VSVDVGEDAS FSCAWRGNPL PRVTWTRRGG AQVLGSGATL
     RLPSVGPEDA GDYVCRAEAG LSGLRGGAAE ARLTVNAPPV VTALHSAPAF LRGPARLQCL
     VFASPAPDAV VWSWDEGFLE AGSQGRFLVE TFPAPESRGG LGPGLISVLH ISGTQESDFS
     RSFNCSARNR LGEGGAQASL GRRASASFSE QKNLMRIPGS SDGSSSRGPE EEETGSREDR
     GPIVHTDHSD LVLEEEGTLE TKDPTNGYYK VRGVSVSLSL GEAPGGGLFL PPPSPLGPPG
     TPTFYDFNPH LGMVPPCRLY RARAGYLTTP HPRAFTSYIK PTSFGPPDLA PGTPPFPYAA
     FPTPSHPRLQ THV
//