ID   K7EJB6_HUMAN            Unreviewed;       318 AA.
AC   K7EJB6;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   05-DEC-2018, entry version 37.
DE   SubName: Full=Proprotein convertase subtilisin/kexin type 4 {ECO:0000313|Ensembl:ENSP00000465102};
DE   Flags: Fragment;
GN   Name=PCSK4 {ECO:0000313|Ensembl:ENSP00000465102};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000465102, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000465102, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000465102}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
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DR   EMBL; AC027307; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EJB6; -.
DR   PeptideAtlas; K7EJB6; -.
DR   PRIDE; K7EJB6; -.
DR   Ensembl; ENST00000591201; ENSP00000465102; ENSG00000115257.
DR   UCSC; uc060rcg.1; human.
DR   EuPathDB; HostDB:ENSG00000115257.15; -.
DR   HGNC; HGNC:8746; PCSK4.
DR   OpenTargets; ENSG00000115257; -.
DR   eggNOG; KOG3525; Eukaryota.
DR   eggNOG; COG1404; LUCA.
DR   eggNOG; COG4935; LUCA.
DR   GeneTree; ENSGT00940000161989; -.
DR   ChiTaRS; PCSK4; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000115257; Expressed in 94 organ(s), highest expression level in right testis.
DR   ExpressionAtlas; K7EJB6; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   Gene3D; 3.30.70.850; -; 1.
DR   Gene3D; 3.40.50.200; -; 1.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR023827; Peptidase_S8_Asp-AS.
DR   InterPro; IPR032815; S8_pro-domain.
DR   InterPro; IPR038466; S8_pro-domain_sf.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   Pfam; PF16470; S8_pro-domain; 1.
DR   SUPFAM; SSF52743; SSF52743; 1.
DR   PROSITE; PS00136; SUBTILASE_ASP; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:K7EJB6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    318       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900711.
FT   DOMAIN       34    110       S8_pro-domain.
FT                                {ECO:0000259|Pfam:PF16470}.
FT   DOMAIN      146    193       Peptidase S8. {ECO:0000259|Pfam:PF00082}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000465102}.
SQ   SEQUENCE   318 AA;  35826 MW;  5A2189A8B4BF4D45 CRC64;
     XPIALWLRLV LALALVRPRA VGWAPVRAPI YVSSWAVQVS QGNREVERLA RKFGFVNLGP
     IFPDGQYFHL RHRGVVQQSL TPHWGHRLHL KKNPKVQWFQ QQTLQRRVKR SVVVPTDPWF
     SKQWYMNSEA QPDLSILQAW SQGLSGQGIV VSVLDDGIEK DHPDLWANYD PLASYDFNDY
     DPDPQPRYTP SKENRRTDAG RYHHRCHRGP VAEPAAAAHP HLQRQLGSRG RRPHGGRPRH
     PHPRGLPAWC DQASTRFPWA APPSRAACPG TAKPAPPPSP PPTAAAWPPT PRSSPRTCIT
     GAQTSTRAPR PQPHWRPA
//