ID   K7EIR2_HUMAN            Unreviewed;        88 AA.
AC   K7EIR2;
DT   09-JAN-2013, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 1.
DT   13-FEB-2019, entry version 36.
DE   RecName: Full=MICOS complex subunit MIC13 {ECO:0000256|RuleBase:RU363009};
GN   Name=MICOS13 {ECO:0000313|Ensembl:ENSP00000464857};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000464857, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000464857, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000464857}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
CC   -!- FUNCTION: Component of the MICOS complex, a large protein complex
CC       of the mitochondrial inner membrane that plays crucial roles in
CC       the maintenance of crista junctions, inner membrane architecture,
CC       and formation of contact sites to the outer membrane.
CC       {ECO:0000256|RuleBase:RU363009}.
CC   -!- SUBUNIT: Component of the mitochondrial contact site and cristae
CC       organizing system (MICOS) complex.
CC       {ECO:0000256|RuleBase:RU363009}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU363009}; Single-pass membrane protein
CC       {ECO:0000256|RuleBase:RU363009}.
CC   -!- SIMILARITY: Belongs to the MICOS complex subunit Mic13 family.
CC       {ECO:0000256|RuleBase:RU363009}.
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DR   EMBL; AC011499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; K7EIR2; -.
DR   jPOST; K7EIR2; -.
DR   MaxQB; K7EIR2; -.
DR   PeptideAtlas; K7EIR2; -.
DR   PRIDE; K7EIR2; -.
DR   Ensembl; ENST00000587589; ENSP00000464857; ENSG00000174917.
DR   UCSC; uc060sbw.1; human.
DR   EuPathDB; HostDB:ENSG00000174917.8; -.
DR   HGNC; HGNC:33702; MICOS13.
DR   OpenTargets; ENSG00000174917; -.
DR   eggNOG; ENOG410J44B; Eukaryota.
DR   eggNOG; ENOG410YRP1; LUCA.
DR   GeneTree; ENSGT00390000002629; -.
DR   OMA; PPKFNFH; -.
DR   ChiTaRS; C19orf70; human.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000174917; Expressed in 195 organ(s), highest expression level in apex of heart.
DR   ExpressionAtlas; K7EIR2; baseline and differential.
DR   GO; GO:0061617; C:MICOS complex; IEA:UniProtKB-UniRule.
DR   InterPro; IPR026769; Mic13.
DR   PANTHER; PTHR31816; PTHR31816; 1.
DR   Pfam; PF15884; QIL1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU363009};
KW   Mitochondrion {ECO:0000256|RuleBase:RU363009};
KW   Mitochondrion inner membrane {ECO:0000256|RuleBase:RU363009};
KW   Proteomics identification {ECO:0000213|EPD:K7EIR2,
KW   ECO:0000213|MaxQB:K7EIR2, ECO:0000213|PeptideAtlas:K7EIR2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19     88       MICOS complex subunit MIC13.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003900689.
SQ   SEQUENCE   88 AA;  9700 MW;  52174008703CDE89 CRC64;
     MVARVWSLMR FLIKGSVAGG AVYLVYDQEL LGPSDKSQAA LQKAGEVVPP AMYQFSQYVC
     QQTGLQIPQL PAPPKIYFPI RDSWNAGI
//