ID   J9JII2_HUMAN            Unreviewed;       120 AA.
AC   J9JII2;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   12-SEP-2018, entry version 42.
DE   SubName: Full=Interleukin-4 receptor subunit alpha {ECO:0000313|Ensembl:ENSP00000455632};
DE   Flags: Fragment;
GN   Name=IL4R {ECO:0000313|Ensembl:ENSP00000455632};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000455632, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000455632, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000455632}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000456930}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (OCT-2012) to UniProtKB.
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DR   EMBL; AC106739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; J9JII2; -.
DR   Ensembl; ENST00000563002; ENSP00000456930; ENSG00000077238.
DR   Ensembl; ENST00000566117; ENSP00000455632; ENSG00000077238.
DR   UCSC; uc059sjl.1; human.
DR   EuPathDB; HostDB:ENSG00000077238.13; -.
DR   HGNC; HGNC:6015; IL4R.
DR   OpenTargets; ENSG00000077238; -.
DR   eggNOG; ENOG410IGBQ; Eukaryota.
DR   eggNOG; ENOG41124QC; LUCA.
DR   GeneTree; ENSGT00510000049182; -.
DR   ChiTaRS; IL4R; human.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000077238; Expressed in 192 organ(s), highest expression level in left adrenal gland.
DR   ExpressionAtlas; J9JII2; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR   GO; GO:0002532; P:production of molecular mediator involved in inflammatory response; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR036116; FN3_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR015319; IL-4_rcpt-alpha_N.
DR   Pfam; PF09238; IL4Ra_N; 1.
DR   SUPFAM; SSF49265; SSF49265; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J9JII2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    120       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014098913.
FT   DOMAIN       28    120       IL4Ra_N. {ECO:0000259|Pfam:PF09238}.
FT   NON_TER     120    120       {ECO:0000313|Ensembl:ENSP00000455632}.
SQ   SEQUENCE   120 AA;  13205 MW;  E04B6E87599A7CEF CRC64;
     MGWLCSGLLF PVSCLVLLQV ASSGNMKVLQ EPTCVSDYMS ISTCEWKMNG PTNCSTELRL
     LYQLVFLLSE AHTCIPENNG GAGCVCHLLM DDVVSADNYT LDLWAGQQLL WKGSFKPSEH
//