ID   J9JIC6_HUMAN            Unreviewed;       145 AA.
AC   J9JIC6;
DT   31-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   31-OCT-2012, sequence version 1.
DT   05-DEC-2018, entry version 42.
DE   SubName: Full=Corticotropin-releasing factor receptor 1 {ECO:0000313|Ensembl:ENSP00000239167};
GN   Name=CRHR1 {ECO:0000313|Ensembl:ENSP00000239167};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000239167, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000239167, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000239167}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2012) to UniProtKB.
RN   [3] {ECO:0000313|Ensembl:ENSP00000488779}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2015) to UniProtKB.
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DR   EMBL; AC217771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC243621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   PeptideAtlas; J9JIC6; -.
DR   PRIDE; J9JIC6; -.
DR   Ensembl; ENST00000347197; ENSP00000239167; ENSG00000120088.
DR   Ensembl; ENST00000632383; ENSP00000488779; ENSG00000276191.
DR   UCSC; uc060giz.1; human.
DR   EuPathDB; HostDB:ENSG00000120088.14; -.
DR   HGNC; HGNC:2357; CRHR1.
DR   OpenTargets; ENSG00000120088; -.
DR   eggNOG; KOG4564; Eukaryota.
DR   eggNOG; ENOG410XRS2; LUCA.
DR   GeneTree; ENSGT00940000158410; -.
DR   ChiTaRS; CRHR1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000120088; Expressed in 63 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; J9JIC6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR003052; GPCR_2_CRF1_rcpt.
DR   InterPro; IPR003051; GPCR_2_CRF_rcpt.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR01279; CRFRECEPTOR.
DR   PRINTS; PR01280; CRFRECEPTOR1.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF111418; SSF111418; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J9JIC6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    145       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014098914.
FT   TRANSMEM    121    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       29    106       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
SQ   SEQUENCE   145 AA;  15916 MW;  8AE700992ED0C504 CRC64;
     MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS GLQCNASVDL IGTCWPRSPA
     GQLVVRPCPA FFYGVRYNTT NNGYRECLAN GSWAARVNYS ECQEILNEEK KSKVHYHVAV
     IINYLGHCIS LVALLVAFVL FLRLS
//