ID   J3QT17_HUMAN            Unreviewed;       236 AA.
AC   J3QT17;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Inactive C-alpha-formylglycine-generating enzyme 2 {ECO:0000313|Ensembl:ENSP00000378823};
GN   Name=SUMF2 {ECO:0000313|Ensembl:ENSP00000378823};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000378823, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000378823, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R.,
RA   Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H.,
RA   Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A.,
RA   Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J.,
RA   Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A.,
RA   Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S.,
RA   Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M.,
RA   Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C.,
RA   Latreille P., Miller N., Johnson D., Murray J., Woessner J.P.,
RA   Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J.,
RA   Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L.,
RA   Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R.,
RA   Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K.,
RA   Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S.,
RA   Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M.,
RA   Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R.,
RA   Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D.,
RA   Waterston R.H., Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000378823}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
RN   [5] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC092101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QT17; -.
DR   SMR; J3QT17; -.
DR   jPOST; J3QT17; -.
DR   MaxQB; J3QT17; -.
DR   PeptideAtlas; J3QT17; -.
DR   PRIDE; J3QT17; -.
DR   Ensembl; ENST00000395435; ENSP00000378823; ENSG00000129103.
DR   UCSC; uc011kcz.3; human.
DR   EuPathDB; HostDB:ENSG00000129103.17; -.
DR   HGNC; HGNC:20415; SUMF2.
DR   OpenTargets; ENSG00000129103; -.
DR   eggNOG; ENOG410IFQ0; Eukaryota.
DR   eggNOG; COG1262; LUCA.
DR   GeneTree; ENSGT00390000008983; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   Bgee; ENSG00000129103; Expressed in 196 organ(s), highest expression level in right uterine tube.
DR   ExpressionAtlas; J3QT17; baseline and differential.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR005532; SUMF_dom.
DR   Pfam; PF03781; FGE-sulfatase; 2.
DR   SUPFAM; SSF56436; SSF56436; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:J3QT17,
KW   ECO:0000213|MaxQB:J3QT17, ECO:0000213|PeptideAtlas:J3QT17};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     44       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        45    236       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003776567.
FT   DOMAIN       46    112       FGE-sulfatase.
FT                                {ECO:0000259|Pfam:PF03781}.
FT   DOMAIN      122    227       FGE-sulfatase.
FT                                {ECO:0000259|Pfam:PF03781}.
SQ   SEQUENCE   236 AA;  25981 MW;  80A9AA8EA9A456EC CRC64;
     MRAHAQRGRG CTRRSAAVLM ARHGLPLLPL LSLLVGAWLK LGNGQATSMV QLQGGRFLMG
     TNSPDSRDGD GPVREATVKP FAIDIFPVTN KDFRDFVREK KYRTEAEMFG WSFVFEDFVS
     DELRNKATQP MKGKFPKGDK AEDGFHGVSP VNAFPAQNNY GLYDLLGNVW EWTASPYQAA
     EQDMRVLRGA SWIDTADGSA NHRARVTTRM GNTPDSASDN LGFRCAADAG RPPGEL
//