ID   J3QT06_HUMAN            Unreviewed;       217 AA.
AC   J3QT06;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   29-OCT-2014, sequence version 2.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Chorionic somatomammotropin hormone-like 1 {ECO:0000313|Ensembl:ENSP00000376569};
GN   Name=CSHL1 {ECO:0000313|Ensembl:ENSP00000376569};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000376569, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000376569, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000376569}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618,
CC       ECO:0000256|SAAS:SAAS00687159}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|RuleBase:RU003618, ECO:0000256|SAAS:SAAS00680088}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC127029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QT06; -.
DR   SMR; J3QT06; -.
DR   jPOST; J3QT06; -.
DR   PeptideAtlas; J3QT06; -.
DR   PRIDE; J3QT06; -.
DR   Ensembl; ENST00000392824; ENSP00000376569; ENSG00000204414.
DR   UCSC; uc060isz.1; human.
DR   EuPathDB; HostDB:ENSG00000204414.11; -.
DR   HGNC; HGNC:2442; CSHL1.
DR   OpenTargets; ENSG00000204414; -.
DR   eggNOG; ENOG410IFR6; Eukaryota.
DR   eggNOG; ENOG4111HU8; LUCA.
DR   GeneTree; ENSGT00730000111012; -.
DR   ChiTaRS; CSHL1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000204414; Expressed in 15 organ(s), highest expression level in placenta.
DR   ExpressionAtlas; J3QT06; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   PANTHER; PTHR11417; PTHR11417; 1.
DR   Pfam; PF00103; Hormone_1; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00835087};
KW   Hormone {ECO:0000256|RuleBase:RU003618};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00119356};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    217       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003777357.
SQ   SEQUENCE   217 AA;  24888 MW;  266EA3463E8EA527 CRC64;
     MATGSRTSLL LAFALLCLPW LQEAGAVQTV PLSRLFKEAM LQAHRAHQLA IDTYQEFEEA
     YITKEQKYSF LHDSQTSFCF SDSIPTSSNM EETQQKSNLE LLHISLLLIE SRLEPVRFLR
     STFTNNLVYD TSDSDDYHLL KDLEEGIQML MGRLEDGSHL TGQTLKQTYS KFDTNSHNHD
     ALLKNYGLLH CFRKDMDKVE TFLRMVQCRS VEGSCGF
//