ID J3QSU6_HUMAN Unreviewed; 2019 AA. AC J3QSU6; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 13-FEB-2019, entry version 56. DE SubName: Full=Tenascin {ECO:0000313|Ensembl:ENSP00000339553}; GN Name=TNC {ECO:0000313|Ensembl:ENSP00000339553}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000339553, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000339553, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15164053; DOI=10.1038/nature02465; RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., RA Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., RA Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., RA Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R., RA Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., RA Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., RA Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., RA Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., RA Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., RA Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., RA Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., RA Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., RA Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., RA Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., RA McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., RA Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., RA Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., RA Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., RA Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., RA Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., RA Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., RA Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R., RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., RA Rogers J., Dunham I.; RT "DNA sequence and analysis of human chromosome 9."; RL Nature 429:369-374(2004). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000339553} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AL162425; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; XP_006717161.1; XM_006717098.3. DR UniGene; Hs.143250; -. DR UniGene; Hs.684865; -. DR UniGene; Hs.734766; -. DR ProteinModelPortal; J3QSU6; -. DR SwissPalm; J3QSU6; -. DR jPOST; J3QSU6; -. DR PeptideAtlas; J3QSU6; -. DR PRIDE; J3QSU6; -. DR Ensembl; ENST00000341037; ENSP00000339553; ENSG00000041982. DR GeneID; 3371; -. DR UCSC; uc064vgq.1; human. DR CTD; 3371; -. DR EuPathDB; HostDB:ENSG00000041982.15; -. DR HGNC; HGNC:5318; TNC. DR OpenTargets; ENSG00000041982; -. DR GeneTree; ENSGT00940000155188; -. DR OrthoDB; 18592at2759; -. DR ChiTaRS; TNC; human. DR GenomeRNAi; 3371; -. DR Proteomes; UP000005640; Chromosome 9. DR Bgee; ENSG00000041982; Expressed in 213 organ(s), highest expression level in layer of synovial tissue. DR ExpressionAtlas; J3QSU6; baseline and differential. DR GO; GO:0062023; C:collagen-containing extracellular matrix; IEA:InterPro. DR GO; GO:0007155; P:cell adhesion; IEA:InterPro. DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:InterPro. DR CDD; cd00063; FN3; 13. DR CDD; cd00087; FReD; 1. DR Gene3D; 2.60.40.10; -; 13. DR InterPro; IPR013032; EGF-like_CS. DR InterPro; IPR000742; EGF-like_dom. DR InterPro; IPR013111; EGF_extracell. DR InterPro; IPR036056; Fibrinogen-like_C. DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom. DR InterPro; IPR003961; FN3_dom. DR InterPro; IPR036116; FN3_sf. DR InterPro; IPR013783; Ig-like_fold. DR InterPro; IPR033078; TNC. DR PANTHER; PTHR19143:SF38; PTHR19143:SF38; 7. DR Pfam; PF07974; EGF_2; 4. DR Pfam; PF00147; Fibrinogen_C; 1. DR Pfam; PF00041; fn3; 13. DR SMART; SM00181; EGF; 14. DR SMART; SM00186; FBG; 1. DR SMART; SM00060; FN3; 13. DR SUPFAM; SSF49265; SSF49265; 10. DR SUPFAM; SSF56496; SSF56496; 1. DR PROSITE; PS00022; EGF_1; 5. DR PROSITE; PS01186; EGF_2; 5. DR PROSITE; PS50026; EGF_3; 5. DR PROSITE; PS51406; FIBRINOGEN_C_2; 1. DR PROSITE; PS50853; FN3; 13. PE 1: Evidence at protein level; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076}; KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076}; KW Proteomics identification {ECO:0000213|EPD:J3QSU6, KW ECO:0000213|MaxQB:J3QSU6, ECO:0000213|PeptideAtlas:J3QSU6}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 2019 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003777214. FT DOMAIN 186 217 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 280 311 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 373 404 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 466 497 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 559 590 EGF-like. {ECO:0000259|PROSITE:PS50026}. FT DOMAIN 625 715 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 716 804 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 805 894 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 895 990 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 991 1075 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1076 1165 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1167 1259 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1260 1348 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1349 1438 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1440 1529 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1530 1619 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1620 1706 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1707 1795 Fibronectin type-III. FT {ECO:0000259|PROSITE:PS50853}. FT DOMAIN 1793 2008 Fibrinogen C-terminal. FT {ECO:0000259|PROSITE:PS51406}. FT COILED 119 139 {ECO:0000256|SAM:Coils}. FT DISULFID 190 200 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 207 216 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 284 294 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 301 310 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 377 387 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 394 403 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 470 480 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 487 496 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 563 573 {ECO:0000256|PROSITE-ProRule:PRU00076}. FT DISULFID 580 589 {ECO:0000256|PROSITE-ProRule:PRU00076}. SQ SEQUENCE 2019 AA; 220853 MW; 8390133DD3663EE9 CRC64; MGAMTQLLAG VFLAFLALAT EGGVLKKVIR HKRQSGVNAT LPEENQPVVF NHVYNIKLPV GSQCSVDLES ASGEKDLAPP SEPSESFQEH TVDGENQIVF THRINIPRRA CGCAAAPDVK ELLSRLEELE NLVSSLREQC TAGAGCCLQP ATGRLDTRPF CSGRGNFSTE GCGCVCEPGW KGPNCSEPEC PGNCHLRGRC IDGQCICDDG FTGEDCSQLA CPSDCNDQGK CVNGVCICFE GYAGADCSRE ICPVPCSEEH GTCVDGLCVC HDGFAGDDCN KPLCLNNCYN RGRCVENECV CDEGFTGEDC SELICPNDCF DRGRCINGTC YCEEGFTGED CGKPTCPHAC HTQGRCEEGQ CVCDEGFAGV DCSEKRCPAD CHNRGRCVDG RCECDDGFTG ADCGELKCPN GCSGHGRCVN GQCVCDEGYT GEDCSQLRCP NDCHSRGRCV EGKCVCEQGF KGYDCSDMSC PNDCHQHGRC VNGMCVCDDG YTGEDCRDRQ CPRDCSNRGL CVDGQCVCED GFTGPDCAEL SCPNDCHGQG RCVNGQCVCH EGFMGKDCKE QRCPSDCHGQ GRCVDGQCIC HEGFTGLDCG QHSCPSDCNN LGQCVSGRCI CNEGYSGEDC SEVSPPKDLV VTEVTEETVN LAWDNEMRVT EYLVVYTPTH EGGLEMQFRV PGDQTSTIIQ ELEPGVEYFI RVFAILENKK SIPVSARVAT YLPAPEGLKF KSIKETSVEV EWDPLDIAFE TWEIIFRNMN KEDEGEITKS LRRPETSYRQ TGLAPGQEYE ISLHIVKNNT RGPGLKRVTT TRLDAPSQIE VKDVTDTTAL ITWFKPLAEI DGIELTYGIK DVPGDRTTID LTEDENQYSI GNLKPDTEYE VSLISRRGDM SSNPAKETFT TGLDAPRNLR RVSQTDNSIT LEWRNGKAAI DSYRIKYAPI SGGDHAEVDV PKSQQATTKT TLTGLRPGTE YGIGVSAVKE DKESNPATIN AATELDTPKD LQVSETAETS LTLLWKTPLA KFDRYRLNYS LPTGQWVGVQ LPRNTTSYVL RGLEPGQEYN VLLTAEKGRH KSKPARVKAS TEQAPELENL TVTEVGWDGL RLNWTAADQA YEHFIIQVQE ANKVEAARNL TVPGSLRAVD IPGLKAATPY TVSIYGVIQG YRTPVLSAEA STGETPNLGE VVVAEVGWDA LKLNWTAPEG AYEYFFIQVQ EADTVEAAQN LTVPGGLRST DLPGLKAATH YTITIRGVTQ DFSTTPLSVE VLTEDLPQLG DLAVSEVGWD GLRLNWTAAD NAYEHFVIQV QEVNKVEAAQ NLTLPGSLRA VDIPGLEAAT PYRVSIYGVI RGYRTPVLSA EASTAKEPEI GNLNVSDITP ESFNLSWMAT DGIFETFTIE IIDSNRLLET VEYNISGAER TAHISGLPPS TDFIVYLSGL APSIRTKTIS ATATTEAEPE VDNLLVSDAT PDGFRLSWTA DEGVFDNFVL KIRDTKKQSE PLEITLLAPE RTRDITGLRE ATEYEIELYG ISKGRRSQTV SAIATTAMGS PKEVIFSDIT ENSATVSWRA PTAQVESFRI TYVPITGGTP SMVTVDGTKT QTRLVKLIPG VEYLVSIIAM KGFEESEPVS GSFTTALDGP SGLVTANITD SEALARWQPA IATVDSYVIS YTGEKVPEIT RTVSGNTVEY ALTDLEPATE YTLRIFAEKG PQKSSTITAK FTTDLDSPRD LTATEVQSET ALLTWRPPRA SVTGYLLVYE SVDGTVKEVI VGPDTTSYSL ADLSPSTHYT AKIQALNGPL RSNMIQTIFT TIGLLYPFPK DCSQAMLNGD TTSGLYTIYL NGDKAEALEV FCDMTSDGGG WIVFLRRKNG RENFYQNWKA YAAGFGDRRE EFWLGLDNLN KITAQGQYEL RVDLRDHGET AFAVYDKFSV GDAKTRYKLK VEGYSGTAGD SMAYHNGRSF STFDKDTDSA ITNCALSYKG AFWYRNCHRV NLMGRYGDNN HSQGVNWFHW KGHEHSIQFA EMKLRPSNFR NLEGRRKRA //