ID   J3QRT5_HUMAN            Unreviewed;       251 AA.
AC   J3QRT5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Intercellular adhesion molecule 2 {ECO:0000313|Ensembl:ENSP00000464372};
GN   Name=ICAM2 {ECO:0000313|Ensembl:ENSP00000464372};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000464372, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000464372, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000464372}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
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DR   EMBL; AC005803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QRT5; -.
DR   SMR; J3QRT5; -.
DR   jPOST; J3QRT5; -.
DR   PeptideAtlas; J3QRT5; -.
DR   PRIDE; J3QRT5; -.
DR   Ensembl; ENST00000578892; ENSP00000464372; ENSG00000108622.
DR   UCSC; uc060itu.1; human.
DR   EuPathDB; HostDB:ENSG00000108622.10; -.
DR   HGNC; HGNC:5345; ICAM2.
DR   OpenTargets; ENSG00000108622; -.
DR   GeneTree; ENSGT00940000161654; -.
DR   ChiTaRS; ICAM2; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108622; Expressed in 221 organ(s), highest expression level in blood.
DR   ExpressionAtlas; J3QRT5; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR003988; ICAM.
DR   InterPro; IPR015653; ICAM2.
DR   InterPro; IPR013768; ICAM_N.
DR   InterPro; IPR003987; ICAM_VCAM_N.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR13771:SF3; PTHR13771:SF3; 2.
DR   Pfam; PF03921; ICAM_N; 1.
DR   PRINTS; PR01473; ICAM.
DR   PRINTS; PR01472; ICAMVCAM1.
DR   SUPFAM; SSF48726; SSF48726; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:J3QRT5,
KW   ECO:0000213|PeptideAtlas:J3QRT5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    251       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003777346.
FT   TRANSMEM    200    224       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36     90       ICAM_N. {ECO:0000259|Pfam:PF03921}.
SQ   SEQUENCE   251 AA;  28182 MW;  A735F8B90986A88D CRC64;
     MSSFGYRTLT VALFTLICCP GSDEKVFEVH VRPKKLATSL DKILLDEQAQ WKHYLVSNIS
     HDTVLQCHFT CSGKQESMNS NVSVYQPPRQ VILTLQPTLV AVGKSFTIEC RVPTVEPLDS
     LTLFLFRGNE TLHYETFGKA APAPQEATAT FNSTADREDG HRNFSCLAVL DLMSRGGNIF
     HKHSAPKMLE IYEPVSDSQM VIIVTVVSVL LSLFVTSVLL CFIFGQHLRQ QRMGTYGVRA
     AWRRLPQAFR P
//