ID   J3QQW1_HUMAN            Unreviewed;       276 AA.
AC   J3QQW1;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 37.
DE   SubName: Full=CD226 antigen {ECO:0000313|Ensembl:ENSP00000463927};
DE   Flags: Fragment;
GN   Name=CD226 {ECO:0000313|Ensembl:ENSP00000463927};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463927, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463927, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463927}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC011930; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC091137; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QQW1; -.
DR   jPOST; J3QQW1; -.
DR   PeptideAtlas; J3QQW1; -.
DR   PRIDE; J3QQW1; -.
DR   Ensembl; ENST00000579496; ENSP00000463927; ENSG00000150637.
DR   UCSC; uc060pzg.1; human.
DR   EuPathDB; HostDB:ENSG00000150637.8; -.
DR   HGNC; HGNC:16961; CD226.
DR   OpenTargets; ENSG00000150637; -.
DR   eggNOG; ENOG410IDXC; Eukaryota.
DR   eggNOG; ENOG41129MS; LUCA.
DR   GeneTree; ENSGT00500000044993; -.
DR   ChiTaRS; CD226; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000150637; Expressed in 108 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; J3QQW1; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 2.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 2.
DR   SMART; SM00409; IG; 2.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 2.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:J3QQW1,
KW   ECO:0000213|PeptideAtlas:J3QQW1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    276       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003777333.
FT   TRANSMEM    249    275       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    110       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      135    239       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   NON_TER     276    276       {ECO:0000313|Ensembl:ENSP00000463927}.
SQ   SEQUENCE   276 AA;  31254 MW;  BC7CAB2785EECC5E CRC64;
     MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW FKIGTQQDSI
     AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE DDVGYYSCSL YTYPQGTWQK
     VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN
     LVHGRNFTSK FPRQIVSNCS HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV
     AEGKTDNQYT LFVAGGTVLL LLFVISITTI IVIFLN
//