ID   J3QLI7_HUMAN            Unreviewed;       720 AA.
AC   J3QLI7;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Leucine-rich repeat-containing protein 37B {ECO:0000313|Ensembl:ENSP00000463564};
GN   Name=LRRC37B {ECO:0000313|Ensembl:ENSP00000463564};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463564, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463564, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463564}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC090616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QLI7; -.
DR   jPOST; J3QLI7; -.
DR   PeptideAtlas; J3QLI7; -.
DR   PRIDE; J3QLI7; -.
DR   Ensembl; ENST00000578674; ENSP00000463564; ENSG00000185158.
DR   UCSC; uc060dsq.1; human.
DR   EuPathDB; HostDB:ENSG00000185158.12; -.
DR   HGNC; HGNC:29070; LRRC37B.
DR   OpenTargets; ENSG00000185158; -.
DR   eggNOG; ENOG410IJNR; Eukaryota.
DR   eggNOG; ENOG410YV94; LUCA.
DR   GeneTree; ENSGT00530000063282; -.
DR   ChiTaRS; LRRC37B; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000185158; Expressed in 92 organ(s), highest expression level in testis.
DR   ExpressionAtlas; J3QLI7; baseline and differential.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR015753; LRRC37.
DR   InterPro; IPR032754; LRRC37_N.
DR   PANTHER; PTHR23045; PTHR23045; 2.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF15779; LRRC37; 2.
DR   SMART; SM00369; LRR_TYP; 4.
DR   PROSITE; PS51450; LRR; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3QLI7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     39       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        40    720       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003777138.
FT   DOMAIN      306    375       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      371    449       LRRC37. {ECO:0000259|Pfam:PF15779}.
SQ   SEQUENCE   720 AA;  80000 MW;  05DACD8B2CF27249 CRC64;
     MAFAECIAPA CVMSWLRFWG PWPLLTWQLL SLLVKEAQPL VWVKDPLQLT SNPLGPPEPW
     SSRSSHLPWE SPHAPAPPAA PGDFDYLGPS ASSQMSALPQ EPTENLAPFL KELDSAGELP
     LGPEPFLAAH QDLNDKRTPE ERLPEVVPLL NRDQNQALVQ LPRLKWVQTT DLDRAAGHQA
     DEILVPLDSK VSRPTKFVVS PKNLKKDLAE RWSLPEIVGI PHQLSKPQRQ KQTLPDDYLS
     MDTLYPGSLP PELRVNADEP PGPPEQVGLS QFHLEPKSQN PETLEDIQSS SLQEEAPAQL
     LQLPQEVEPS TQQEAPALPP ESSMESLAQT PLNHEVTVQP PGEDQAHYNL PKFTVKPADV
     EVTMTSEPKN ETESTQAQQE APIQPPEEAE PSSTALRTTD PPPEHPEVTL PPSDKGQAQH
     SHLTEATVQP LDLELSITTE PTTEVKPSPT TEETSAQPPD PGLAITPEPT TEIGHSTALE
     KTRAPHPDQV QTLHRSLTEV TGPPTKLESS QDSLVQSETA PEEQKASTST NICELCTCGD
     ETLSCVGLSP KQRLRQVPVP EPDTYNGIFT TLNFQGNYIS YLDGNVWKAY SWTEKLILSE
     NYLTELPKDS FEGLLYLQYL DLSCNKIRYI ERQTFESLPF LQYINLGCNL ITKLSLGTFQ
     AWHGMQFLHN LILNRNPLTT VEDPYLFELP ALKYLDMGTT HITLTTLKNI LTMTVELEKL
//