ID   J3QL83_HUMAN            Unreviewed;        90 AA.
AC   J3QL83;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 42.
DE   SubName: Full=Receptor tyrosine-protein kinase erbB-2 {ECO:0000313|Ensembl:ENSP00000463427};
GN   Name=ERBB2 {ECO:0000313|Ensembl:ENSP00000463427};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463427, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463427, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463427}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC079199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3QL83; -.
DR   jPOST; J3QL83; -.
DR   PeptideAtlas; J3QL83; -.
DR   PRIDE; J3QL83; -.
DR   Ensembl; ENST00000578373; ENSP00000463427; ENSG00000141736.
DR   UCSC; uc060eta.1; human.
DR   EuPathDB; HostDB:ENSG00000141736.13; -.
DR   HGNC; HGNC:3430; ERBB2.
DR   OpenTargets; ENSG00000141736; -.
DR   eggNOG; KOG1025; Eukaryota.
DR   eggNOG; ENOG410XNSR; LUCA.
DR   GeneTree; ENSGT00940000158232; -.
DR   ChiTaRS; ERBB2; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000141736; Expressed in 212 organ(s), highest expression level in esophagus mucosa.
DR   ExpressionAtlas; J3QL83; baseline and differential.
DR   Gene3D; 3.80.20.20; -; 1.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:J3QL83,
KW   ECO:0000213|PeptideAtlas:J3QL83};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23     90       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003776443.
SQ   SEQUENCE   90 AA;  9741 MW;  FAF8BF9CB677A85D CRC64;
     MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
     ELTYLPTNAS LSFLQVRPVG NPARPCLQLG
//