ID   J3QKU0_HUMAN            Unreviewed;       148 AA.
AC   J3QKU0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   13-FEB-2019, entry version 38.
DE   RecName: Full=Post-GPI attachment to proteins factor 3 {ECO:0000256|RuleBase:RU365066};
GN   Name=PGAP3 {ECO:0000313|Ensembl:ENSP00000463234};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463234, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463234, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463234}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. {ECO:0000256|RuleBase:RU365066}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU365066}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU365066}.
CC   -!- SIMILARITY: Belongs to the PGAP3 family.
CC       {ECO:0000256|RuleBase:RU365066}.
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DR   EMBL; AC087491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001278662.1; NM_001291733.1.
DR   UniGene; Hs.462971; -.
DR   ProteinModelPortal; J3QKU0; -.
DR   EPD; J3QKU0; -.
DR   PRIDE; J3QKU0; -.
DR   Ensembl; ENST00000579146; ENSP00000463234; ENSG00000161395.
DR   GeneID; 93210; -.
DR   UCSC; uc010cvz.3; human.
DR   CTD; 93210; -.
DR   EuPathDB; HostDB:ENSG00000161395.12; -.
DR   HGNC; HGNC:23719; PGAP3.
DR   OpenTargets; ENSG00000161395; -.
DR   eggNOG; KOG2970; Eukaryota.
DR   eggNOG; COG5237; LUCA.
DR   GeneTree; ENSGT00390000001304; -.
DR   OrthoDB; 828384at2759; -.
DR   GenomeRNAi; 93210; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000161395; Expressed in 213 organ(s), highest expression level in left lobe of thyroid gland.
DR   ExpressionAtlas; J3QKU0; baseline and differential.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniRule.
DR   InterPro; IPR007217; Per1-like.
DR   PANTHER; PTHR13148; PTHR13148; 1.
DR   Pfam; PF04080; Per1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU365066};
KW   GPI-anchor biosynthesis {ECO:0000256|RuleBase:RU365066};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3QKU0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU365066}.
FT   SIGNAL        1     20       {ECO:0000256|RuleBase:RU365066}.
FT   CHAIN        21    148       Post-GPI attachment to proteins factor 3.
FT                                {ECO:0000256|RuleBase:RU365066}.
FT                                /FTId=PRO_5016481432.
SQ   SEQUENCE   148 AA;  16454 MW;  B6DB976880176FC5 CRC64;
     MAGLAARLVL LAGAAALASG SQGDREPVYR DCVLQCEEQN CSGGALNHFR SRQPIYMSLA
     GWTCRDDCKY ECMWVTVGLY LQEGHKVPQF HGKWPFSRFL FFQEPASAVA SFLNGLASLV
     MLCRYRTFVP ASSPMYHTCV AFAWLSGR
//