ID   J3KTP0_HUMAN            Unreviewed;       908 AA.
AC   J3KTP0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Leucine-rich repeat-containing protein 37B {ECO:0000313|Ensembl:ENSP00000463081};
GN   Name=LRRC37B {ECO:0000313|Ensembl:ENSP00000463081};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463081, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463081, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463081}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC090616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KTP0; -.
DR   jPOST; J3KTP0; -.
DR   PeptideAtlas; J3KTP0; -.
DR   PRIDE; J3KTP0; -.
DR   Ensembl; ENST00000584368; ENSP00000463081; ENSG00000185158.
DR   UCSC; uc060dsr.1; human.
DR   EuPathDB; HostDB:ENSG00000185158.12; -.
DR   HGNC; HGNC:29070; LRRC37B.
DR   OpenTargets; ENSG00000185158; -.
DR   GeneTree; ENSGT00530000063282; -.
DR   ChiTaRS; LRRC37B; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000185158; Expressed in 92 organ(s), highest expression level in testis.
DR   ExpressionAtlas; J3KTP0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR015753; LRRC37.
DR   InterPro; IPR032754; LRRC37_N.
DR   InterPro; IPR029423; LRRC37AB_C.
DR   PANTHER; PTHR23045; PTHR23045; 3.
DR   Pfam; PF13855; LRR_8; 1.
DR   Pfam; PF15779; LRRC37; 2.
DR   Pfam; PF14914; LRRC37AB_C; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KTP0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     39       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        40    908       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003771685.
FT   TRANSMEM    867    889       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      306    375       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      371    449       LRRC37. {ECO:0000259|Pfam:PF15779}.
FT   DOMAIN      756    898       LRRC37AB_C. {ECO:0000259|Pfam:PF14914}.
FT   COILED      837    857       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   908 AA;  100776 MW;  FD8801D7A5DAA2F5 CRC64;
     MAFAECIAPA CVMSWLRFWG PWPLLTWQLL SLLVKEAQPL VWVKDPLQLT SNPLGPPEPW
     SSRSSHLPWE SPHAPAPPAA PGDFDYLGPS ASSQMSALPQ EPTENLAPFL KELDSAGELP
     LGPEPFLAAH QDLNDKRTPE ERLPEVVPLL NRDQNQALVQ LPRLKWVQTT DLDRAAGHQA
     DEILVPLDSK VSRPTKFVVS PKNLKKDLAE RWSLPEIVGI PHQLSKPQRQ KQTLPDDYLS
     MDTLYPGSLP PELRVNADEP PGPPEQVGLS QFHLEPKSQN PETLEDIQSS SLQEEAPAQL
     LQLPQEVEPS TQQEAPALPP ESSMESLAQT PLNHEVTVQP PGEDQAHYNL PKFTVKPADV
     EVTMTSEPKN ETESTQAQQE APIQPPEEAE PSSTALRTTD PPPEHPEVTL PPSDKGQAQH
     SHLTEATVQP LDLELSITTE PTTEVKPSPT TEETSAQPPD PGLAITPEPT TEIGHSTALE
     KTRAPHPDQV QTLHRSLTEV TGPPTKLESS QDSLVQSETA PEEQKASTST NICELCTCGD
     ETLSCVGLSP KQRLRQVPVP EPDTYNGIFT TLNFQGNYIS YLDGNVWKAY SWTEKLILSE
     NYLTELPKDS FEGLLYLQYL ILNRNPLTTV EDPYLFELPA LKYLDMGTTH ITLTTLKNIL
     TMTVELEKLI LPSHMACCLC QFKNSIEAVC KTVKLHCNTA CLTNSIHCPE EASVGNPEGA
     FMKMLQARKQ HMSTQLTIES EAPSDSSGIN LSGFGGDQLE IQLTEQLRSL IPNEDVRKFM
     SHVIRTLKME CSETHVQGSC AKLMLRTGLL MKLLSEQQEA KALNVEWDTD QQKTNYINEN
     MEQNEQKEQK SSELMKEVPG DDYKNKLIFA ISVTVILIIL IIIFCLIEVN SHKRASEKYK
     DNPSISGA
//