ID   J3KTJ2_HUMAN            Unreviewed;       150 AA.
AC   J3KTJ2;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   13-FEB-2019, entry version 27.
DE   RecName: Full=Post-GPI attachment to proteins factor 3 {ECO:0000256|RuleBase:RU365066};
DE   Flags: Fragment;
GN   Name=PGAP3 {ECO:0000313|Ensembl:ENSP00000463011};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000463011, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000463011, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000463011}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- FUNCTION: Involved in the lipid remodeling steps of GPI-anchor
CC       maturation. {ECO:0000256|RuleBase:RU365066}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000256|RuleBase:RU365066}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU365066}.
CC   -!- SIMILARITY: Belongs to the PGAP3 family.
CC       {ECO:0000256|RuleBase:RU365066}.
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DR   EMBL; AC087491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KTJ2; -.
DR   Ensembl; ENST00000584620; ENSP00000463011; ENSG00000161395.
DR   UCSC; uc060ess.1; human.
DR   EuPathDB; HostDB:ENSG00000161395.12; -.
DR   HGNC; HGNC:23719; PGAP3.
DR   OpenTargets; ENSG00000161395; -.
DR   eggNOG; KOG2970; Eukaryota.
DR   eggNOG; COG5237; LUCA.
DR   GeneTree; ENSGT00390000001304; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000161395; Expressed in 213 organ(s), highest expression level in left lobe of thyroid gland.
DR   ExpressionAtlas; J3KTJ2; baseline and differential.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniRule.
DR   InterPro; IPR007217; Per1-like.
DR   PANTHER; PTHR13148; PTHR13148; 1.
DR   Pfam; PF04080; Per1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Golgi apparatus {ECO:0000256|RuleBase:RU365066};
KW   GPI-anchor biosynthesis {ECO:0000256|RuleBase:RU365066};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KTJ2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|RuleBase:RU365066}.
FT   SIGNAL        1     19       {ECO:0000256|RuleBase:RU365066}.
FT   CHAIN        20    150       Post-GPI attachment to proteins factor 3.
FT                                {ECO:0000256|RuleBase:RU365066}.
FT                                /FTId=PRO_5016478541.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000463011}.
SQ   SEQUENCE   150 AA;  16945 MW;  DD47396C5E4E196F CRC64;
     XARLVLLAGA AALASGSQGD REPVYRDCVL QCEEQNCSGG ALNHFRSRQP IYMSLAGWTC
     RDDCKYECMW VTVGLYLQEG HKVPQFHGKW PFSRFLFFQE PASAVASFLN GLASLVMLCR
     YRTFVPASSP MYHTCVAFAW MRKLRHSKAK
//