ID   J3KTH8_HUMAN            Unreviewed;       164 AA.
AC   J3KTH8;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 38.
DE   SubName: Full=Granulocyte colony-stimulating factor {ECO:0000313|Ensembl:ENSP00000462991};
GN   Name=CSF3 {ECO:0000313|Ensembl:ENSP00000462991};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462991, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462991, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000462991}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC090844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KTH8; -.
DR   PeptideAtlas; J3KTH8; -.
DR   PRIDE; J3KTH8; -.
DR   Ensembl; ENST00000577675; ENSP00000462991; ENSG00000108342.
DR   UCSC; uc010wep.3; human.
DR   EuPathDB; HostDB:ENSG00000108342.12; -.
DR   HGNC; HGNC:2438; CSF3.
DR   OpenTargets; ENSG00000108342; -.
DR   GeneTree; ENSGT00390000017328; -.
DR   ChiTaRS; CSF3; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000108342; Expressed in 128 organ(s), highest expression level in smooth muscle tissue.
DR   ExpressionAtlas; J3KTH8; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0005125; F:cytokine activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:InterPro.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   PANTHER; PTHR10511; PTHR10511; 2.
DR   Pfam; PF16647; GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:J3KTH8,
KW   ECO:0000213|PeptideAtlas:J3KTH8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    164       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003771683.
SQ   SEQUENCE   164 AA;  17684 MW;  900C45F4D3252179 CRC64;
     MSPEPALSPA LQLLLWHSAL WTVQEATPLG PASSLPQSFL LKCLEQVRKI QGDGAALQEK
     LAGCLSQLHS GLFLYQGLLQ ALEGISPELG PTLDTLQLDV ADFATTIWQQ MEELGMAPAL
     QPTQGAMPAF ASAFQRRAGG VLVASHLQSF LEVSYRVLRH LAQP
//