ID   J3KT24_HUMAN            Unreviewed;       180 AA.
AC   J3KT24;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 45.
DE   SubName: Full=Macrosialin {ECO:0000313|Ensembl:ENSP00000462768};
DE   Flags: Fragment;
GN   Name=CD68 {ECO:0000313|Ensembl:ENSP00000462768};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462768, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462768, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000462768}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000256|PROSITE-
CC       ProRule:PRU00740}; Single-pass type I membrane protein
CC       {ECO:0000256|PROSITE-ProRule:PRU00740}.
CC   -!- SIMILARITY: Belongs to the LAMP family. {ECO:0000256|PROSITE-
CC       ProRule:PRU00740}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00740}.
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DR   EMBL; AC016876; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KT24; -.
DR   jPOST; J3KT24; -.
DR   PeptideAtlas; J3KT24; -.
DR   Ensembl; ENST00000584502; ENSP00000462768; ENSG00000129226.
DR   UCSC; uc060asc.1; human.
DR   EuPathDB; HostDB:ENSG00000129226.13; -.
DR   HGNC; HGNC:1693; CD68.
DR   OpenTargets; ENSG00000129226; -.
DR   GeneTree; ENSGT00940000153572; -.
DR   ChiTaRS; CD68; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000129226; Expressed in 96 organ(s), highest expression level in leukocyte.
DR   ExpressionAtlas; J3KT24; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR002000; Lysosome-assoc_membr_glycop.
DR   PANTHER; PTHR11506; PTHR11506; 2.
DR   PROSITE; PS51407; LAMP_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Lysosome {ECO:0000256|PROSITE-ProRule:PRU00740};
KW   Membrane {ECO:0000256|PROSITE-ProRule:PRU00740};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KT24};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|PROSITE-ProRule:PRU00740}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18    180       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008419040.
FT   NON_TER     180    180       {ECO:0000313|Ensembl:ENSP00000462768}.
SQ   SEQUENCE   180 AA;  18507 MW;  A415167443CBECB0 CRC64;
     MRLAVLFSGA LLGLLAATLL PSFTVTPTVT ESTGTTSHRT TKSHKTTTHR TTTTGTTSHG
     PTTATHNPTT TSHGNVTVHP TSNSTATSQG PSTATHSPAT TSHGNATVHP TSNSTATSPG
     FTSSAHPEPP PPSPSPSPTS KETIGDYTWT NGSQPCVHLQ AQIQIRVMYT TQGGGEAWGI
//