ID   J3KT03_HUMAN            Unreviewed;       207 AA.
AC   J3KT03;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   07-NOV-2018, entry version 49.
DE   SubName: Full=WD repeat and SOCS box-containing protein 1 {ECO:0000313|Ensembl:ENSP00000462737};
DE   Flags: Fragment;
GN   Name=WSB1 {ECO:0000313|Ensembl:ENSP00000462737};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462737, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462737, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000462737}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC026254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KT03; -.
DR   PeptideAtlas; J3KT03; -.
DR   PRIDE; J3KT03; -.
DR   Ensembl; ENST00000581440; ENSP00000462737; ENSG00000109046.
DR   UCSC; uc060ctx.1; human.
DR   EuPathDB; HostDB:ENSG00000109046.14; -.
DR   HGNC; HGNC:19221; WSB1.
DR   OpenTargets; ENSG00000109046; -.
DR   eggNOG; ENOG410IQ0Y; Eukaryota.
DR   eggNOG; ENOG411010D; LUCA.
DR   GeneTree; ENSGT00890000139406; -.
DR   ChiTaRS; WSB1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000109046; Expressed in 235 organ(s), highest expression level in upper lobe of lung.
DR   ExpressionAtlas; J3KT03; baseline and differential.
DR   InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR017986; WD40_repeat_dom.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF50998; SSF50998; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 2.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:J3KT03,
KW   ECO:0000213|PeptideAtlas:J3KT03};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00756755};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221,
KW   ECO:0000256|SAAS:SAAS00756638}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    207       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003771976.
FT   DOMAIN      143    207       WD_REPEATS_REGION.
FT                                {ECO:0000259|PROSITE:PS50294}.
FT   REPEAT      143    172       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   REPEAT      173    207       WD. {ECO:0000256|PROSITE-
FT                                ProRule:PRU00221}.
FT   NON_TER     207    207       {ECO:0000313|Ensembl:ENSP00000462737}.
SQ   SEQUENCE   207 AA;  23506 MW;  5B204EC99AE8B18B CRC64;
     MASFPPRVNE KEIVFLFFLL VRLRTIGELL APAAPFDKKC GRENWTVAFA PDGSYFAWSQ
     GHRTVKLVPW SQCLQNFLLH GTKNVTNSSS LRLPRQNSDG GQKNKPREHI IDCGDIVWSL
     AFGSSVPEKQ SRCVNIEWHR FRFGQDQLLL ATGLNNGRIK IWDVYTGKLL LNLVDHTEVV
     RDLTFAPDGS LILVSASRDK TLRVWDL
//