ID J3KSS9_HUMAN Unreviewed; 372 AA. AC J3KSS9; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 16-JAN-2019, entry version 50. DE SubName: Full=C-C chemokine receptor type 7 {ECO:0000313|Ensembl:ENSP00000462631}; GN Name=CCR7 {ECO:0000313|Ensembl:ENSP00000462631}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462631, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000462631, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16625196; DOI=10.1038/nature04689; RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., RA Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J., RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., RA Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., RA Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., RA Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., RA Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., RA Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., RA Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., RA Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.; RT "DNA sequence of human chromosome 17 and analysis of rearrangement in RT the human lineage."; RL Nature 440:1045-1049(2006). RN [2] {ECO:0000313|Ensembl:ENSP00000462631} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000256|RuleBase:RU000688, ECO:0000256|SAAS:SAAS00594957}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC004585; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR RefSeq; NP_001288645.1; NM_001301716.1. DR RefSeq; NP_001288646.1; NM_001301717.1. DR RefSeq; NP_001288647.1; NM_001301718.1. DR UniGene; Hs.370036; -. DR ProteinModelPortal; J3KSS9; -. DR PRIDE; J3KSS9; -. DR Ensembl; ENST00000579344; ENSP00000462631; ENSG00000126353. DR GeneID; 1236; -. DR UCSC; uc060eyz.1; human. DR CTD; 1236; -. DR EuPathDB; HostDB:ENSG00000126353.3; -. DR HGNC; HGNC:1608; CCR7. DR OpenTargets; ENSG00000126353; -. DR eggNOG; ENOG410IMBE; Eukaryota. DR eggNOG; ENOG4110ZGY; LUCA. DR GeneTree; ENSGT00940000153132; -. DR OrthoDB; 715251at2759; -. DR GenomeRNAi; 1236; -. DR Proteomes; UP000005640; Chromosome 17. DR Bgee; ENSG00000126353; Expressed in 122 organ(s), highest expression level in blood. DR ExpressionAtlas; J3KSS9; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IDA:HPA. DR GO; GO:0016493; F:C-C chemokine receptor activity; IEA:InterPro. DR GO; GO:0006935; P:chemotaxis; IEA:InterPro. DR GO; GO:0006955; P:immune response; IEA:InterPro. DR GO; GO:0006954; P:inflammatory response; IEA:InterPro. DR InterPro; IPR001718; Chemokine_CCR7. DR InterPro; IPR000355; Chemokine_rcpt. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00657; CCCHEMOKINER. DR PRINTS; PR00641; CHEMOKINER7. DR PRINTS; PR00237; GPCRRHODOPSN. DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00522141}; KW Membrane {ECO:0000256|SAAS:SAAS00522140, ECO:0000256|SAM:Phobius}; KW Proteomics identification {ECO:0000213|MaxQB:J3KSS9, KW ECO:0000213|PeptideAtlas:J3KSS9}; KW Receptor {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00522141}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transducer {ECO:0000256|RuleBase:RU000688, KW ECO:0000256|SAAS:SAAS00522141}; KW Transmembrane {ECO:0000256|SAAS:SAAS00522140, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00522140, KW ECO:0000256|SAM:Phobius}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 372 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003772096. FT TRANSMEM 53 78 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 90 110 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 116 144 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 165 185 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 219 243 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 255 273 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 304 323 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 69 320 G_PROTEIN_RECEP_F1_2. FT {ECO:0000259|PROSITE:PS50262}. SQ SEQUENCE 372 AA; 42232 MW; 6BAC116ADF458B5B CRC64; MKSVLVVALL VIFQVCLCQD EVTDDYIGDN TTVDYTLFES LCSKKDVRNF KAWFLPIMYS IICFVGLLGN GLVVLTYIYF KRLKTMTDTY LLNLAVADIL FLLTLPFWAY SAAKSWVFGV HFCKLIFAIY KMSFFSGMLL LLCISIDRYV AIVQAVSAHR HRARVLLISK LSCVGIWILA TVLSIPELLY SDLQRSSSEQ AMRCSLITEH VEAFITIQVA QMVIGFLVPL LAMSFCYLVI IRTLLQARNF ERNKAIKVII AVVVVFIVFQ LPYNGVVLAQ TVANFNITSS TCELSKQLNI AYDVTYSLAC VRCCVNPFLY AFIGVKFRND LFKLFKDLGC LSQEQLRQWS SCRHIRRSSM SVEAETTTTF SP //