ID   J3KSI6_HUMAN            Unreviewed;       232 AA.
AC   J3KSI6;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 43.
DE   SubName: Full=Desmoglein-2 {ECO:0000313|Ensembl:ENSP00000462503};
GN   Name=DSG2 {ECO:0000313|Ensembl:ENSP00000462503};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462503, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462503, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D.,
RA   Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S.,
RA   Bloom T., Bugalter B., Butler J., Cook A., DeCaprio D., Engels R.,
RA   Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T.,
RA   Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E.,
RA   Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H.,
RA   O'Leary S.B., O'Neill K., Piqani B., Smith C.L., Talamas J.A.,
RA   Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q.,
RA   Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y.,
RA   Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000462503}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC021549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC079096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KSI6; -.
DR   SMR; J3KSI6; -.
DR   jPOST; J3KSI6; -.
DR   MaxQB; J3KSI6; -.
DR   PeptideAtlas; J3KSI6; -.
DR   PRIDE; J3KSI6; -.
DR   Ensembl; ENST00000585206; ENSP00000462503; ENSG00000046604.
DR   UCSC; uc060ofs.1; human.
DR   EuPathDB; HostDB:ENSG00000046604.12; -.
DR   HGNC; HGNC:3049; DSG2.
DR   OpenTargets; ENSG00000046604; -.
DR   eggNOG; KOG3594; Eukaryota.
DR   eggNOG; ENOG410XQHI; LUCA.
DR   GeneTree; ENSGT00910000144083; -.
DR   ChiTaRS; DSG2; human.
DR   Proteomes; UP000005640; Chromosome 18.
DR   Bgee; ENSG00000046604; Expressed in 183 organ(s), highest expression level in mucosa of sigmoid colon.
DR   ExpressionAtlas; J3KSI6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR   InterPro; IPR002126; Cadherin-like_dom.
DR   InterPro; IPR015919; Cadherin-like_sf.
DR   InterPro; IPR020894; Cadherin_CS.
DR   InterPro; IPR009122; Desmosomal_cadherin.
DR   PANTHER; PTHR24025; PTHR24025; 1.
DR   Pfam; PF00028; Cadherin; 1.
DR   PRINTS; PR00205; CADHERIN.
DR   SMART; SM00112; CA; 1.
DR   SUPFAM; SSF49313; SSF49313; 2.
DR   PROSITE; PS00232; CADHERIN_1; 1.
PE   1: Evidence at protein level;
KW   Calcium {ECO:0000256|SAAS:SAAS00020193};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00616217};
KW   Proteomics identification {ECO:0000213|EPD:J3KSI6,
KW   ECO:0000213|MaxQB:J3KSI6, ECO:0000213|PeptideAtlas:J3KSI6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00436611};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00616217};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}.
FT   SIGNAL        1     23       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        24    232       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003773039.
FT   DOMAIN       70    157       CA. {ECO:0000259|SMART:SM00112}.
SQ   SEQUENCE   232 AA;  25939 MW;  031B300E56CD8E89 CRC64;
     MARSPGRAYA LLLLLICFNV GSGLHLQVLS TRNENKLLPK HPHLVRQKRA WITAPVALRE
     GEDLSKKNPI AKIHSDLAEE RGLKITYKYT GKGITEPPFG IFVFNKDTGE LNVTSILDRE
     ETPFFLLTGY ALDARGNNVE KPLELRIKVL DINDNEPVFT QDVFVGSVEE LSAAHTLVMK
     INATDADEPN TLNSKISYRI VSLEPAYPPV FYLNKDTGEI YTTSVTLDRE VS
//