ID   J3KRM0_HUMAN            Unreviewed;       265 AA.
AC   J3KRM0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   12-SEP-2018, entry version 36.
DE   SubName: Full=Zona pellucida-binding protein 2 {ECO:0000313|Ensembl:ENSP00000462067};
GN   Name=ZPBP2 {ECO:0000313|Ensembl:ENSP00000462067};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000462067, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000462067, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000462067}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AC090844; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KRM0; -.
DR   PeptideAtlas; J3KRM0; -.
DR   PRIDE; J3KRM0; -.
DR   Ensembl; ENST00000584588; ENSP00000462067; ENSG00000186075.
DR   UCSC; uc060eud.1; human.
DR   EuPathDB; HostDB:ENSG00000186075.12; -.
DR   HGNC; HGNC:20678; ZPBP2.
DR   OpenTargets; ENSG00000186075; -.
DR   eggNOG; ENOG410IHHK; Eukaryota.
DR   eggNOG; ENOG410YFNT; LUCA.
DR   GeneTree; ENSGT00520000055647; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000186075; Expressed in 30 organ(s), highest expression level in sperm.
DR   ExpressionAtlas; J3KRM0; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0007339; P:binding of sperm to zona pellucida; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR010857; Sp38-bd.
DR   PANTHER; PTHR15443; PTHR15443; 2.
DR   Pfam; PF07354; Sp38; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KRM0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    265       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003771667.
FT   DOMAIN       21    127       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   265 AA;  30073 MW;  96561DD3BD574233 CRC64;
     MMRTCVLLSA VLWCLTGVQC PRFTLFNKKG FIYGKTGQPD KIYVELHQNS PVLICMDFKL
     SKKEIVDPTY LWIGPNEKTL TGNNRINITE TGQLMVKDFL EPLSGLYTCT LSYKTVKAET
     QEEKTVKKRY DFMVFVNPFA PGWKGACNGS VDCEDTTNHN ILQARDRIED FFRSQAYIFY
     HNFNKTLPAM HFVDHSLQVV RLDSCRPGFG KNERLHSNCA SCCVVCSPAT FSPDVNVTCQ
     TCVSVLTYGA KSCPQTSNKN QQYED
//