ID   J3KPQ0_HUMAN            Unreviewed;       734 AA.
AC   J3KPQ0;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   13-FEB-2019, entry version 59.
DE   RecName: Full=Fibroblast growth factor receptor {ECO:0000256|PIRNR:PIRNR000628};
DE            EC=2.7.10.1 {ECO:0000256|PIRNR:PIRNR000628};
GN   Name=FGFR4 {ECO:0000313|Ensembl:ENSP00000377259};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000377259, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000377259, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T.,
RA   Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M.,
RA   Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K.,
RA   Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C.,
RA   Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M.,
RA   Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A.,
RA   Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M.,
RA   Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S.,
RA   Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000377259}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-
CC         tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136,
CC         Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC         EC=2.7.10.1; Evidence={ECO:0000256|PIRNR:PIRNR000628,
CC         ECO:0000256|SAAS:SAAS01124082};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family. Fibroblast growth factor receptor subfamily.
CC       {ECO:0000256|PIRNR:PIRNR000628}.
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DR   EMBL; AC027314; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001278909.1; NM_001291980.1.
DR   UniGene; Hs.165950; -.
DR   ProteinModelPortal; J3KPQ0; -.
DR   SMR; J3KPQ0; -.
DR   jPOST; J3KPQ0; -.
DR   MaxQB; J3KPQ0; -.
DR   PeptideAtlas; J3KPQ0; -.
DR   PRIDE; J3KPQ0; -.
DR   Ensembl; ENST00000393648; ENSP00000377259; ENSG00000160867.
DR   GeneID; 2264; -.
DR   UCSC; uc011dfu.3; human.
DR   CTD; 2264; -.
DR   EuPathDB; HostDB:ENSG00000160867.14; -.
DR   HGNC; HGNC:3691; FGFR4.
DR   OpenTargets; ENSG00000160867; -.
DR   eggNOG; KOG0200; Eukaryota.
DR   eggNOG; COG0515; LUCA.
DR   GeneTree; ENSGT00940000161469; -.
DR   OrthoDB; 220433at2759; -.
DR   ChiTaRS; FGFR4; human.
DR   GenomeRNAi; 2264; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   Bgee; ENSG00000160867; Expressed in 119 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; J3KPQ0; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005007; F:fibroblast growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 3.
DR   InterPro; IPR016248; FGF_rcpt_fam.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008266; Tyr_kinase_AS.
DR   InterPro; IPR020635; Tyr_kinase_cat_dom.
DR   Pfam; PF07679; I-set; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   PIRSF; PIRSF000628; FGFR; 2.
DR   PRINTS; PR00109; TYRKINASE.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 3.
DR   SMART; SM00219; TyrKc; 1.
DR   SUPFAM; SSF48726; SSF48726; 3.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE   1: Evidence at protein level;
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00708816};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00916669};
KW   Immunoglobulin domain {ECO:0000256|SAAS:SAAS00941986};
KW   Kinase {ECO:0000256|PIRNR:PIRNR000628, ECO:0000256|SAAS:SAAS00582553};
KW   Membrane {ECO:0000256|SAAS:SAAS00602683};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00708816};
KW   Proteomics identification {ECO:0000213|MaxQB:J3KPQ0,
KW   ECO:0000213|PeptideAtlas:J3KPQ0};
KW   Receptor {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00600436};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00457685};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00582553};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00602683};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00602683};
KW   Tyrosine-protein kinase {ECO:0000256|PIRNR:PIRNR000628,
KW   ECO:0000256|SAAS:SAAS00582553}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    734       Fibroblast growth factor receptor.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003771633.
FT   DOMAIN      152    240       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      249    349       Ig-like. {ECO:0000259|PROSITE:PS50835}.
FT   DOMAIN      399    687       Protein kinase.
FT                                {ECO:0000259|PROSITE:PS50011}.
FT   ACT_SITE    544    544       Proton acceptor.
FT                                {ECO:0000256|PIRSR:PIRSR000628-1}.
SQ   SEQUENCE   734 AA;  80466 MW;  33FE53DD99570C52 CRC64;
     MRLLLALLGV LLSVPGPPVL SLEASEEVEL EPCLAPSLEQ QEQELTVALG QPVRLCCGRA
     ERGGHWYKEG SRLAPAGRVR GWRGRLEIAS FLPEDAGRYL CLARGSMIVL QNLTLITGDS
     LTSSNDDEDP KSHRDPSNRH SYPQQAPYWT HPQRMEKKLH AVPAGNTVKF RCPAAGNPTP
     TIRWLKDGQA FHGENRIGGI RLRHQHWSLV MESVVPSDRG TYTCLVENAV GSIRYNYLLD
     VLERSPHRPI LQAGLPANTT AVVGSDVELL CKVYSDAQPH IQWLKHIVIN GSSFGADGFP
     YVQVLKTADI NSSEVEVLYL RNVSAEDAGE YTCLAGNSIG LSYQSAWLTV LPEEDPTWTA
     AAPEASSPWS QALPASQAHP WYEACVSPPA APPCSPASLV LGKPLGEGCF GQVVRAEAFG
     MDPARPDQAS TVAVKMLKDN ASDKDLADLV SEMEVMKLIG RHKNIINLLG VCTQEGPLYV
     IVECAAKGNL REFLRARRPP GPDLSPDGPR SSEGPLSFPV LVSCAYQVAR GMQYLESRKC
     IHRDLAARNV LVTEDNVMKI ADFGLARGVH HIDYYKKTSN GRLPVKWMAP EALFDRVYTH
     QSDVWSFGIL LWEIFTLGGS PYPGIPVEEL FSLLREGHRM DRPPHCPPEL YGLMRECWHA
     APSQRPTFKQ LVEALDKVLL AVSEEYLDLR LTFGPYSPSG GDASSTCSSS DSVFSHDPLP
     LGSSSFPFGS GVQT
//