ID   J3KP74_HUMAN            Unreviewed;       853 AA.
AC   J3KP74;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   12-SEP-2018, entry version 44.
DE   SubName: Full=Proteoglycan 4 {ECO:0000313|Ensembl:ENSP00000356452};
DE   Flags: Fragment;
GN   Name=PRG4 {ECO:0000313|Ensembl:ENSP00000356452};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000356452, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000356452, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000213|PubMed:18088087}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18088087; DOI=10.1021/pr0704130;
RA   Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,
RA   Schutz C., Walter U., Gambaryan S., Sickmann A.;
RT   "Phosphoproteome of resting human platelets.";
RL   J. Proteome Res. 7:526-534(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000356452}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AL133553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; J3KP74; -.
DR   PeptideAtlas; J3KP74; -.
DR   PRIDE; J3KP74; -.
DR   Ensembl; ENST00000367482; ENSP00000356452; ENSG00000116690.
DR   UCSC; uc057nyr.1; human.
DR   EuPathDB; HostDB:ENSG00000116690.12; -.
DR   HGNC; HGNC:9364; PRG4.
DR   OpenTargets; ENSG00000116690; -.
DR   eggNOG; KOG1565; Eukaryota.
DR   eggNOG; ENOG410XQ5D; LUCA.
DR   GeneTree; ENSGT00530000063751; -.
DR   ChiTaRS; PRG4; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000116690; Expressed in 117 organ(s), highest expression level in synovial joint.
DR   ExpressionAtlas; J3KP74; baseline and differential.
DR   GO; GO:0030247; F:polysaccharide binding; IEA:InterPro.
DR   GO; GO:0005044; F:scavenger receptor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   InterPro; IPR036024; Somatomedin_B-like_dom_sf.
DR   InterPro; IPR020436; Somatomedin_B_chordata.
DR   InterPro; IPR001212; Somatomedin_B_dom.
DR   Pfam; PF01033; Somatomedin_B; 1.
DR   PRINTS; PR00022; SOMATOMEDINB.
DR   SMART; SM00201; SO; 1.
DR   SUPFAM; SSF90188; SSF90188; 1.
DR   PROSITE; PS00524; SMB_1; 1.
DR   PROSITE; PS50958; SMB_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:J3KP74,
KW   ECO:0000213|PeptideAtlas:J3KP74};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25    853       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008419039.
FT   DOMAIN       25     67       SMB. {ECO:0000259|PROSITE:PS50958}.
FT   NON_TER     853    853       {ECO:0000313|Ensembl:ENSP00000356452}.
SQ   SEQUENCE   853 AA;  89368 MW;  0203B4E055F1CF93 CRC64;
     MAWKTLPIYL LLLLSVFVIQ QVSSQELSCK GRCFESFERG RECDCDAQCK KYDKCCPDYE
     SFCAEVKDNK KNRTKKKPTP KPPVVDEAGS GLDNGDFKVT TPDTSTTQHN KVSTSPKITT
     AKPINPRPSL PPNSDTSKET SLTVNKETTV ETKETTTTNK QTSTDGKEKT TSAKETQSIE
     KTSAKDLAPT SKVLAKPTPK AETTTKGPAL TTPKEPTPTT PKEPASTTPK EPTPTTIKSA
     PTTPKEPAPT TTKSAPTTPK EPAPTTTKEP APTTPKEPAP TTTKEPAPTT TKSAPTTPKE
     PAPTTPKKPA PTTPKEPAPT TPKEPTPTTP KEPAPTTKEP APTTPKEPAP TAPKKPAPTT
     PKEPAPTTPK EPAPTTTKEP SPTTPKEPAP TTTKSAPTTT KEPAPTTTKS APTTPKEPSP
     TTTKEPAPTT PKEPAPTTPK KPAPTTPKEP APTTPKEPAP TTTKKPAPTT PKEPAPTTPK
     ETAPTTPKKL TPTTPEKLAP TTPEKPAPTT PEELAPTTPE EPTPTTPEEP APTTPKAAAP
     NTPKEPAPTT PKEPAPTTPK EPAPTTPKET APTTPKGTAP TTLKEPAPTT PKKPAPKELA
     PTTTKEPTST TSDKPAPTTP KGTAPTTPKE PAPTTPKEPA PTTPKGTAPT TLKEPAPTTP
     KKPAPKELAP TTTKGPTSTT SDKPAPTTPK ETAPTTPKEP APTTPKKPAP TTPETPPPTT
     SEVSTPTTTK EPTTIHKSPD ESTPELSAEP TPKALENSPK EPGVPTTKTP AATKPEMTTT
     AKDKTTERDL RTTPETTTAA PKMTKETATT TEKTTESKIT ATTTQVTSTT TQDTTPFKIT
     TLKTTTLAPK VTT
//