ID   J3KNP7_HUMAN            Unreviewed;       250 AA.
AC   J3KNP7;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Sperm-egg fusion protein Juno {ECO:0000313|Ensembl:ENSP00000332963};
GN   Name=IZUMO1R {ECO:0000313|Ensembl:ENSP00000332963};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000332963, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000332963, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000332963}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
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DR   EMBL; AP002784; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001186135.1; NM_001199206.1.
DR   UniGene; Hs.553758; -.
DR   ProteinModelPortal; J3KNP7; -.
DR   SMR; J3KNP7; -.
DR   PRIDE; J3KNP7; -.
DR   Ensembl; ENST00000328458; ENSP00000332963; ENSG00000183560.
DR   GeneID; 390243; -.
DR   KEGG; hsa:390243; -.
DR   UCSC; uc058gov.1; human.
DR   CTD; 390243; -.
DR   EuPathDB; HostDB:ENSG00000183560.8; -.
DR   HGNC; HGNC:32565; IZUMO1R.
DR   OpenTargets; ENSG00000183560; -.
DR   eggNOG; ENOG410IFFP; Eukaryota.
DR   eggNOG; ENOG4111IU4; LUCA.
DR   GeneTree; ENSGT00940000154321; -.
DR   KO; K13649; -.
DR   OMA; FPHYFPT; -.
DR   OrthoDB; 1224404at2759; -.
DR   PhylomeDB; J3KNP7; -.
DR   GenomeRNAi; 390243; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000183560; Expressed in 33 organ(s), highest expression level in lymph node.
DR   ExpressionAtlas; J3KNP7; baseline and differential.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:Ensembl.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR   GO; GO:0007155; P:cell adhesion; IEA:Ensembl.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:Ensembl.
DR   GO; GO:0035036; P:sperm-egg recognition; IEA:Ensembl.
DR   InterPro; IPR004269; Folate_rcpt.
DR   InterPro; IPR018143; Folate_rcpt-like.
DR   PANTHER; PTHR10517; PTHR10517; 1.
DR   Pfam; PF03024; Folate_rec; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KNP7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    250       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008419038.
FT   DOMAIN       26    208       Folate_rec. {ECO:0000259|Pfam:PF03024}.
SQ   SEQUENCE   250 AA;  28672 MW;  CBF2FD967ABAF6E7 CRC64;
     MACWWPLLLE LWTVMPTWAG DELLNICMNA KHHKRVPSPE DKLYEECIPW KDNACCTLTT
     SWEAHLDVSP LYNFSLFHCG LLMPGCRKHF IQAICFYECS PNLGPWIQPV GSLGWEVAPS
     GQGERVVNVP LCQEDCEEWW EDCRMSYTCK SNWRGGWDWS QGKNRCPKGA QCLPFSHYFP
     TPADLCEKTW SNSFKASPER RNSGRCLQKW FEPAQGNPNV AVARLFASSA PSWELSYTIM
     VCSLFLPFLS
//