ID   J3KNP4_HUMAN            Unreviewed;       837 AA.
AC   J3KNP4;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 63.
DE   SubName: Full=Semaphorin-4B {ECO:0000313|Ensembl:ENSP00000332204};
GN   Name=SEMA4B {ECO:0000313|Ensembl:ENSP00000332204};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000332204, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000213|PubMed:17081983}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA   Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,
RA   Mann M.;
RT   "Global, in vivo, and site-specific phosphorylation dynamics in
RT   signaling networks.";
RL   Cell 127:635-648(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000332204, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R.,
RA   Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G.,
RA   Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A.,
RA   Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W.,
RA   Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X.,
RA   Sneddon K.M., Stewart S., Sougnez C., Stone S.M., Topham K.,
RA   Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S.,
RA   Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human
RT   chromosome 15.";
RL   Nature 440:671-675(2006).
RN   [3] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [4] {ECO:0000313|Ensembl:ENSP00000332204}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
RN   [5] {ECO:0000213|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- SIMILARITY: Belongs to the semaphorin family.
CC       {ECO:0000256|SAAS:SAAS00692871}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR   EMBL; AC091167; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_064595.2; NM_020210.3.
DR   RefSeq; NP_945119.1; NM_198925.2.
DR   UniGene; Hs.474935; -.
DR   EPD; J3KNP4; -.
DR   jPOST; J3KNP4; -.
DR   MaxQB; J3KNP4; -.
DR   PeptideAtlas; J3KNP4; -.
DR   PRIDE; J3KNP4; -.
DR   Ensembl; ENST00000332496; ENSP00000332204; ENSG00000185033.
DR   Ensembl; ENST00000411539; ENSP00000394720; ENSG00000185033.
DR   GeneID; 10509; -.
DR   KEGG; hsa:10509; -.
DR   UCSC; uc002boy.4; human.
DR   CTD; 10509; -.
DR   EuPathDB; HostDB:ENSG00000185033.14; -.
DR   HGNC; HGNC:10730; SEMA4B.
DR   OpenTargets; ENSG00000185033; -.
DR   eggNOG; KOG3611; Eukaryota.
DR   eggNOG; ENOG410XQZC; LUCA.
DR   GeneTree; ENSGT00940000154870; -.
DR   KO; K06521; -.
DR   OMA; CQNYIKI; -.
DR   OrthoDB; 64683at2759; -.
DR   TreeFam; TF352903; -.
DR   ChiTaRS; SEMA4B; human.
DR   GenomeRNAi; 10509; -.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000185033; Expressed in 166 organ(s), highest expression level in ectocervix.
DR   ExpressionAtlas; J3KNP4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; IEA:Ensembl.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR016201; PSI.
DR   InterPro; IPR001627; Semap_dom.
DR   InterPro; IPR036352; Semap_dom_sf.
DR   InterPro; IPR027231; Semaphorin.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR11036; PTHR11036; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SUPFAM; SSF101912; SSF101912; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00656526};
KW   Membrane {ECO:0000256|SAAS:SAAS00106123, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|MaxQB:J3KNP4,
KW   ECO:0000213|PeptideAtlas:J3KNP4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00106123,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     43       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        44    837       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014098586.
FT   TRANSMEM    718    738       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       47    523       Sema. {ECO:0000259|PROSITE:PS51004}.
SQ   SEQUENCE   837 AA;  92766 MW;  3C9F27C0E68A1E21 CRC64;
     MLRTAMGLRS WLAAPWGALP PRPPLLLLLL LLLLLQPPPP TWALSPRISL PLGSEERPFL
     RFEAEHISNY TALLLSRDGR TLYVGAREAL FALSSNLSFL PGGEYQELLW GADAEKKQQC
     SFKGKDPQRD CQNYIKILLP LSGSHLFTCG TAAFSPMCTY INMENFTLAR DEKGNVLLED
     GKGRCPFDPN FKSTALVVDG ELYTGTVSSF QGNDPAISRS QSLRPTKTES SLNWLQDPAF
     VASAYIPESL GSLQGDDDKI YFFFSETGQE FEFFENTIVS RIARICKGDE GGERVLQQRW
     TSFLKAQLLC SRPDDGFPFN VLQDVFTLSP SPQDWRDTLF YGVFTSQWHR GTTEGSAVCV
     FTMKDVQRVF SGLYKEVNRE TQQWYTVTHP VPTPRPGACI TNSARERKIN SSLQLPDRVL
     NFLKDHFLMD GQVRSRMLLL QPQARYQRVA VHRVPGLHHT YDVLFLGTGD GRLHKAVSVG
     PRVHIIEELQ IFSSGQPVQN LLLDTHRGLL YAASHSGVVQ VPMANCSLYR SCGDCLLARD
     PYCAWSGSSC KHVSLYQPQL ATRPWIQDIE GASAKDLCSA SSVVSPSFVP TGEKPCEQVQ
     FQPNTVNTLA CPLLSNLATR LWLRNGAPVN ASASCHVLPT GDLLLVGTQQ LGEFQCWSLE
     EGFQQLVASY CPEVVEDGVA DQTDEGGSVP VIISTSRVSA PAGGKASWGA DRSYWKEFLV
     MCTLFVLAVL LPVLFLLYRH RNSMKVFLKQ GECASVHPKT CPVVLPPETR PLNGLGPPST
     PLDHRGYQSL SDSPPGSRVF TESEKRPLSI QDSFVEVSPV CPRPRVRLGS EIRDSVV
//