ID   J3KNC5_HUMAN            Unreviewed;       838 AA.
AC   J3KNC5;
DT   03-OCT-2012, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2012, sequence version 1.
DT   16-JAN-2019, entry version 59.
DE   SubName: Full=NEL-like 1 (Chicken), isoform CRA_a {ECO:0000313|EMBL:EAW68326.1};
DE   SubName: Full=Protein kinase C-binding protein NELL1 {ECO:0000313|Ensembl:ENSP00000298925};
GN   Name=NELL1 {ECO:0000313|EMBL:EAW68326.1,
GN   ECO:0000313|Ensembl:ENSP00000298925};
GN   ORFNames=hCG_1811036 {ECO:0000313|EMBL:EAW68326.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000298925, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|EMBL:EAW68326.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=11181995; DOI=10.1126/science.1058040;
RA   Venter J.C., Adams M.D., Myers E.W., Li P.W., Mural R.J., Sutton G.G.,
RA   Smith H.O., Yandell M., Evans C.A., Holt R.A., Gocayne J.D.,
RA   Amanatides P., Ballew R.M., Huson D.H., Wortman J.R., Zhang Q.,
RA   Kodira C.D., Zheng X.H., Chen L., Skupski M., Subramanian G.,
RA   Thomas P.D., Zhang J., Gabor Miklos G.L., Nelson C., Broder S.,
RA   Clark A.G., Nadeau J., McKusick V.A., Zinder N., Levine A.J.,
RA   Roberts R.J., Simon M., Slayman C., Hunkapiller M., Bolanos R.,
RA   Delcher A., Dew I., Fasulo D., Flanigan M., Florea L., Halpern A.,
RA   Hannenhalli S., Kravitz S., Levy S., Mobarry C., Reinert K.,
RA   Remington K., Abu-Threideh J., Beasley E., Biddick K., Bonazzi V.,
RA   Brandon R., Cargill M., Chandramouliswaran I., Charlab R.,
RA   Chaturvedi K., Deng Z., Di Francesco V., Dunn P., Eilbeck K.,
RA   Evangelista C., Gabrielian A.E., Gan W., Ge W., Gong F., Gu Z.,
RA   Guan P., Heiman T.J., Higgins M.E., Ji R.R., Ke Z., Ketchum K.A.,
RA   Lai Z., Lei Y., Li Z., Li J., Liang Y., Lin X., Lu F., Merkulov G.V.,
RA   Milshina N., Moore H.M., Naik A.K., Narayan V.A., Neelam B.,
RA   Nusskern D., Rusch D.B., Salzberg S., Shao W., Shue B., Sun J.,
RA   Wang Z., Wang A., Wang X., Wang J., Wei M., Wides R., Xiao C., Yan C.,
RA   Yao A., Ye J., Zhan M., Zhang W., Zhang H., Zhao Q., Zheng L.,
RA   Zhong F., Zhong W., Zhu S., Zhao S., Gilbert D., Baumhueter S.,
RA   Spier G., Carter C., Cravchik A., Woodage T., Ali F., An H., Awe A.,
RA   Baldwin D., Baden H., Barnstead M., Barrow I., Beeson K., Busam D.,
RA   Carver A., Center A., Cheng M.L., Curry L., Danaher S., Davenport L.,
RA   Desilets R., Dietz S., Dodson K., Doup L., Ferriera S., Garg N.,
RA   Gluecksmann A., Hart B., Haynes J., Haynes C., Heiner C., Hladun S.,
RA   Hostin D., Houck J., Howland T., Ibegwam C., Johnson J., Kalush F.,
RA   Kline L., Koduru S., Love A., Mann F., May D., McCawley S.,
RA   McIntosh T., McMullen I., Moy M., Moy L., Murphy B., Nelson K.,
RA   Pfannkoch C., Pratts E., Puri V., Qureshi H., Reardon M.,
RA   Rodriguez R., Rogers Y.H., Romblad D., Ruhfel B., Scott R., Sitter C.,
RA   Smallwood M., Stewart E., Strong R., Suh E., Thomas R., Tint N.N.,
RA   Tse S., Vech C., Wang G., Wetter J., Williams S., Williams M.,
RA   Windsor S., Winn-Deen E., Wolfe K., Zaveri J., Zaveri K., Abril J.F.,
RA   Guigo R., Campbell M.J., Sjolander K.V., Karlak B., Kejariwal A.,
RA   Mi H., Lazareva B., Hatton T., Narechania A., Diemer K.,
RA   Muruganujan A., Guo N., Sato S., Bafna V., Istrail S., Lippert R.,
RA   Schwartz R., Walenz B., Yooseph S., Allen D., Basu A., Baxendale J.,
RA   Blick L., Caminha M., Carnes-Stine J., Caulk P., Chiang Y.H.,
RA   Coyne M., Dahlke C., Mays A., Dombroski M., Donnelly M., Ely D.,
RA   Esparham S., Fosler C., Gire H., Glanowski S., Glasser K., Glodek A.,
RA   Gorokhov M., Graham K., Gropman B., Harris M., Heil J., Henderson S.,
RA   Hoover J., Jennings D., Jordan C., Jordan J., Kasha J., Kagan L.,
RA   Kraft C., Levitsky A., Lewis M., Liu X., Lopez J., Ma D., Majoros W.,
RA   McDaniel J., Murphy S., Newman M., Nguyen T., Nguyen N., Nodell M.,
RA   Pan S., Peck J., Peterson M., Rowe W., Sanders R., Scott J.,
RA   Simpson M., Smith T., Sprague A., Stockwell T., Turner R., Venter E.,
RA   Wang M., Wen M., Wu D., Wu M., Xia A., Zandieh A., Zhu X.;
RT   "The sequence of the human genome.";
RL   Science 291:1304-1351(2001).
RN   [2] {ECO:0000313|EMBL:EAW68326.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSP00000298925, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [4] {ECO:0000313|Ensembl:ENSP00000298925}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (AUG-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; AC010811; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC067794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC069575; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC087279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090707; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC099730; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC105190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF455349; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471064; EAW68326.1; -; Genomic_DNA.
DR   RefSeq; NP_001275642.1; NM_001288713.1.
DR   UniGene; Hs.657172; -.
DR   SMR; J3KNC5; -.
DR   PeptideAtlas; J3KNC5; -.
DR   PRIDE; J3KNC5; -.
DR   Ensembl; ENST00000298925; ENSP00000298925; ENSG00000165973.
DR   GeneID; 4745; -.
DR   UCSC; uc009yid.5; human.
DR   CTD; 4745; -.
DR   EuPathDB; HostDB:ENSG00000165973.17; -.
DR   HGNC; HGNC:7750; NELL1.
DR   OpenTargets; ENSG00000165973; -.
DR   eggNOG; ENOG410IR7C; Eukaryota.
DR   eggNOG; ENOG410XSZA; LUCA.
DR   GeneTree; ENSGT00810000125439; -.
DR   OMA; RRNGEDW; -.
DR   OrthoDB; 767046at2759; -.
DR   ChiTaRS; NELL1; human.
DR   GenomeRNAi; 4745; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000165973; Expressed in 116 organ(s), highest expression level in stomach.
DR   ExpressionAtlas; J3KNC5; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR024731; EGF_dom.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR001007; VWF_dom.
DR   Pfam; PF12947; EGF_3; 1.
DR   Pfam; PF07645; EGF_CA; 3.
DR   Pfam; PF00093; VWC; 2.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 5.
DR   SMART; SM00282; LamG; 1.
DR   SMART; SM00210; TSPN; 1.
DR   SMART; SM00214; VWC; 4.
DR   SMART; SM00215; VWC_out; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 5.
DR   PROSITE; PS01187; EGF_CA; 2.
DR   PROSITE; PS01208; VWFC_1; 2.
DR   PROSITE; PS50184; VWFC_2; 2.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:J3KNC5};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    838       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014098590.
FT   DOMAIN      299    360       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   DOMAIN      462    503       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      504    544       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      545    575       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      577    615       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      624    659       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      720    778       VWFC. {ECO:0000259|PROSITE:PS50184}.
FT   COILED      268    288       {ECO:0000256|SAM:Coils}.
FT   DISULFID    547    557       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    565    574       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   838 AA;  92825 MW;  36A53F65F125DA48 CRC64;
     MPMDLILVVW FCVCTARTAE DMKPPVLSLI WRTRVLKSLL QQSLQGVVGF GMDPDLQMDI
     VTELDLVNTT LGVAQVSGMH NASKAFLFQD IEREIHAAPH VSEKLIQLFR NKSEFTILAT
     VQQKPSTSGV ILSIRELEHS YFELESSGLR DEIRYHYIHN GKPRTEALPY RMADGQWHKV
     ALSVSASHLL LHVDCNRIYE RVIDPPDTNL PPGINLWLGQ RNQKHGLFKG IIQDGKIIFM
     PNGYITQCPN LNHTCPTCSD FLSLVQGIMD LQELLAKMTA KLNYAETRLS QLENCHCEKT
     CQVSGLLYRD QDSWVDGDHC RNCTCKSGAV ECRRMSCPPL NCSPDSLPVH IAGQCCKVCR
     PKCIYGGKVL AEGQRILTKS CRECRGGVLV KITEMCPPLN CSEKDHILPE NQCCRVCRGH
     NFCAEGPKCG ENSECKNWNT KATCECKSGY ISVQGDSAYC EDIDECAAKM HYCHANTVCV
     NLPGLYRCDC VPGYIRVDDF SCTEHDECGS GQHNCDENAI CTNTVQGHSC TCKPGYVGNG
     TICRAFCEEG CRYGGTCVAP NKCVCPSGFT GSHCEKDIDE CSEGIIECHN HSRCVNLPGW
     YHCECRSGFH DDGTYSLSGE SCIDIDECAL RTHTCWNDSA CINLAGGFDC LCPSGPSCSG
     DCPHEGGLKH NGQVWTLKED RCSVCSCKDG KIFCRRTACD CQNPSADLFC CPECDTRVTS
     QCLDQNGHKL YRSGDNWTHS CQQCRCLEGE VDCWPLTCPN LSCEYTAILE GECCPRCVSD
     PCLADNITYD IRKTCLDSYG VSRLSGSVWT MAGSPCTTCK CKNGRVCCSV DFECLQNN
//