ID J3KMX3_HUMAN Unreviewed; 622 AA. AC J3KMX3; DT 03-OCT-2012, integrated into UniProtKB/TrEMBL. DT 03-OCT-2012, sequence version 1. DT 16-JAN-2019, entry version 46. DE SubName: Full=Alpha-fetoprotein {ECO:0000313|Ensembl:ENSP00000226359}; GN Name=AFP {ECO:0000313|Ensembl:ENSP00000226359}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000226359, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000226359, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15815621; DOI=10.1038/nature03466; RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., RA Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., RA Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., RA Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J., RA Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., RA Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., RA Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., RA Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., RA Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., RA Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., RA Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., RA Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., RA Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., RA Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., RA Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., RA Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., RA Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., RA Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., RA McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., RA Waterston R.H., Wilson R.K.; RT "Generation and annotation of the DNA sequences of human chromosomes 2 RT and 4."; RL Nature 434:724-731(2005). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000226359} RP IDENTIFICATION. RG Ensembl; RL Submitted (AUG-2012) to UniProtKB. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC108157; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; J3KMX3; -. DR SMR; J3KMX3; -. DR jPOST; J3KMX3; -. DR PeptideAtlas; J3KMX3; -. DR PRIDE; J3KMX3; -. DR Ensembl; ENST00000226359; ENSP00000226359; ENSG00000081051. DR UCSC; uc062xgg.1; human. DR EuPathDB; HostDB:ENSG00000081051.7; -. DR HGNC; HGNC:317; AFP. DR OpenTargets; ENSG00000081051; -. DR eggNOG; ENOG410IIRZ; Eukaryota. DR eggNOG; ENOG410Z40H; LUCA. DR GeneTree; ENSGT00390000000113; -. DR OMA; AECCKLP; -. DR PhylomeDB; J3KMX3; -. DR ChiTaRS; AFP; human. DR Proteomes; UP000005640; Chromosome 4. DR Bgee; ENSG00000081051; Expressed in 68 organ(s), highest expression level in embryo. DR ExpressionAtlas; J3KMX3; baseline and differential. DR GO; GO:0005615; C:extracellular space; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd00015; ALBUMIN; 3. DR InterPro; IPR000264; ALB/AFP/VDB. DR InterPro; IPR020858; Serum_albumin-like. DR InterPro; IPR021177; Serum_albumin/AFP/Afamin. DR InterPro; IPR020857; Serum_albumin_CS. DR InterPro; IPR014760; Serum_albumin_N. DR PANTHER; PTHR11385; PTHR11385; 1. DR Pfam; PF00273; Serum_albumin; 3. DR PIRSF; PIRSF002520; Serum_albumin_subgroup; 1. DR PRINTS; PR00803; AFETOPROTEIN. DR PRINTS; PR00802; SERUMALBUMIN. DR SMART; SM00103; ALBUMIN; 3. DR SUPFAM; SSF48552; SSF48552; 3. DR PROSITE; PS00212; ALBUMIN_1; 1. DR PROSITE; PS51438; ALBUMIN_2; 3. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Disulfide bond {ECO:0000256|PIRSR:PIRSR002520-2}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR002520-1}; KW Proteomics identification {ECO:0000213|EPD:J3KMX3, KW ECO:0000213|MaxQB:J3KMX3, ECO:0000213|PeptideAtlas:J3KMX3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|PIRSR:PIRSR002520-1}. FT SIGNAL 1 18 {ECO:0000256|SAM:SignalP}. FT CHAIN 19 622 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003771599. FT DOMAIN 19 210 Albumin. {ECO:0000259|PROSITE:PS51438}. FT DOMAIN 211 402 Albumin. {ECO:0000259|PROSITE:PS51438}. FT DOMAIN 403 601 Albumin. {ECO:0000259|PROSITE:PS51438}. FT METAL 273 273 Zinc. {ECO:0000256|PIRSR:PIRSR002520-1}. FT DISULFID 99 114 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 113 124 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 148 193 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 192 201 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 224 270 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 269 277 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 289 303 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 302 313 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 384 393 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 416 462 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 461 472 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 485 501 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 500 511 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 538 583 {ECO:0000256|PIRSR:PIRSR002520-2}. FT DISULFID 582 591 {ECO:0000256|PIRSR:PIRSR002520-2}. SQ SEQUENCE 622 AA; 70450 MW; DA036E52F6F52737 CRC64; MKWVESIFLI FLLNFTESRT LHRNEYGIAS ILDSYQCTAE ISLADLATIF FAQFVQEATY KEVSKMVKDA LTAIEKPTGD EQSSGCLENQ LPAFLEELCH EKEILEKYGH SDCCSQSEEG RHNCFLAHKK PTPASIPLFQ VPEPVTSCEA YEEDRETFMN KFIYEIARRH PFLYAPTILL WAARYDKIIP SCCKAENAVE CFQTKAATVT KELRESSLLN QHACAVMKNF GTRTFQAITV TKLSQKFTKV NFTEIQKLVL DVAHVHEHCC RGDVLDCLQD GEKIMSYICS QQDTLSNKIT ECCKLTTLER GQCIIHAEND EKPEGLSPNL NRFLGDRDFN QFSSGEKNIF LASFVHEYSR RHPQLAVSVI LRVAKGYQEL LEKCFQTENP LECQDKGEEE LQKYIQESQA LAKRSCGLFQ KLGEYYLQNA FLVAYTKKAP QLTSSELMAI TRKMAATAAT CCQLSEDKLL ACGEGAADII IGHLCIRHEM TPVNPGVGQC CTSSYANRRP CFSSLVVDET YVPPAFSDDK FIFHKDLCQA QGVALQTMKQ EFLINLVKQK PQITEEQLEA VIADFSGLLE KCCQGQEQEV CFAEEGKRRQ NESFIRCELF SLILTDLTLF VN //