ID   I3L4Z0_HUMAN            Unreviewed;       128 AA.
AC   I3L4Z0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 44.
DE   SubName: Full=Pigment epithelium-derived factor {ECO:0000313|Ensembl:ENSP00000461660};
DE   Flags: Fragment;
GN   Name=SERPINF1 {ECO:0000313|Ensembl:ENSP00000461660};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000461660, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000461660, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:22905912}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22905912; DOI=10.1021/pr300539b;
RA   Rosenow A., Noben J.P., Jocken J., Kallendrusch S.,
RA   Fischer-Posovszky P., Mariman E.C., Renes J.;
RT   "Resveratrol-induced changes of the human adipocyte secretion
RT   profile.";
RL   J. Proteome Res. 11:4733-4743(2012).
RN   [3] {ECO:0000313|Ensembl:ENSP00000461660}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|SAAS:SAAS00596534}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC130343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC130689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L4Z0; -.
DR   jPOST; I3L4Z0; -.
DR   MaxQB; I3L4Z0; -.
DR   PeptideAtlas; I3L4Z0; -.
DR   PRIDE; I3L4Z0; -.
DR   Ensembl; ENST00000571360; ENSP00000461660; ENSG00000132386.
DR   UCSC; uc059zjc.1; human.
DR   EuPathDB; HostDB:ENSG00000132386.10; -.
DR   HGNC; HGNC:8824; SERPINF1.
DR   OpenTargets; ENSG00000132386; -.
DR   GeneTree; ENSGT00940000158112; -.
DR   ChiTaRS; SERPINF1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000132386; Expressed in 226 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; I3L4Z0; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:I3L4Z0,
KW   ECO:0000213|PeptideAtlas:I3L4Z0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    128       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003675292.
FT   DOMAIN       44    124       SERPIN. {ECO:0000259|Pfam:PF00079}.
FT   NON_TER     128    128       {ECO:0000313|Ensembl:ENSP00000461660}.
SQ   SEQUENCE   128 AA;  13803 MW;  A772CC184168F996 CRC64;
     MQALVLLLCI GALLGHSSCQ NPASPPEEEE DPFFKVPVNK LAAAVSNFGY DLYRVRSSTS
     PTTNVLLSPL SVATALSALS LGAEQRTESI IHRALYYDLI SSPDIHGTYK ELLDTVTAPQ
     KNLKSASR
//