ID I3L4H3_HUMAN Unreviewed; 114 AA. AC I3L4H3; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 05-DEC-2018, entry version 43. DE RecName: Full=Dipeptidase {ECO:0000256|RuleBase:RU341113}; DE EC=3.4.13.19 {ECO:0000256|RuleBase:RU341113}; DE Flags: Fragment; GN Name=DPEP2 {ECO:0000313|Ensembl:ENSP00000461250}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000461250, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000461250, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000461250} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=Hydrolysis of dipeptides.; EC=3.4.13.19; CC Evidence={ECO:0000256|RuleBase:RU341113}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|RuleBase:RU341113}; CC -!- SUBUNIT: Homodimer; disulfide-linked. CC {ECO:0000256|RuleBase:RU341113}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU341113}; CC Lipid-anchor, GPI-anchor {ECO:0000256|RuleBase:RU341113}. CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases CC superfamily. Peptidase M19 family. CC {ECO:0000256|RuleBase:RU341113}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC040162; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KC877614; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3L4H3; -. DR PeptideAtlas; I3L4H3; -. DR PRIDE; I3L4H3; -. DR Ensembl; ENST00000574865; ENSP00000461250; ENSG00000167261. DR UCSC; uc059wce.1; human. DR EuPathDB; HostDB:ENSG00000167261.13; -. DR HGNC; HGNC:23028; DPEP2. DR OpenTargets; ENSG00000167261; -. DR eggNOG; KOG4127; Eukaryota. DR eggNOG; COG2355; LUCA. DR GeneTree; ENSGT00940000160211; -. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000167261; Expressed in 125 organ(s), highest expression level in blood. DR ExpressionAtlas; I3L4H3; baseline and differential. DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0016805; F:dipeptidase activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW. DR InterPro; IPR028531; Dpep2. DR InterPro; IPR008257; Pept_M19. DR PANTHER; PTHR10443; PTHR10443; 1. DR PANTHER; PTHR10443:SF9; PTHR10443:SF9; 1. DR PROSITE; PS51365; RENAL_DIPEPTIDASE_2; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Dipeptidase {ECO:0000256|RuleBase:RU341113}; KW Disulfide bond {ECO:0000256|RuleBase:RU341113}; KW Glycoprotein {ECO:0000256|RuleBase:RU341113}; KW GPI-anchor {ECO:0000256|RuleBase:RU341113}; KW Hydrolase {ECO:0000256|RuleBase:RU341113}; KW Lipoprotein {ECO:0000256|RuleBase:RU341113}; KW Membrane {ECO:0000256|RuleBase:RU341113}; KW Metal-binding {ECO:0000256|RuleBase:RU341113}; KW Metalloprotease {ECO:0000256|RuleBase:RU341113}; KW Protease {ECO:0000256|RuleBase:RU341113}; KW Proteomics identification {ECO:0000213|MaxQB:I3L4H3, KW ECO:0000213|PeptideAtlas:I3L4H3}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|RuleBase:RU341113}; KW Zinc {ECO:0000256|RuleBase:RU341113}. FT SIGNAL 1 32 {ECO:0000256|RuleBase:RU341113}. FT CHAIN 33 114 Dipeptidase. FT {ECO:0000256|RuleBase:RU341113}. FT /FTId=PRO_5009031249. FT NON_TER 114 114 {ECO:0000313|Ensembl:ENSP00000461250}. SQ SEQUENCE 114 AA; 12414 MW; 74D52C6BF4FA4D47 CRC64; MQPSGLEGPG TFGRWPLLSL LLLLLLLQPV TCAYTTPGPP RALTTLGAPR AHTMPGTYAP STTLSSPSTQ GLQEQARALM RDFPLVDGHN DLPLVLRQVY QKGLQDVNLR NFSY //