ID   I3L454_HUMAN            Unreviewed;       523 AA.
AC   I3L454;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 50.
DE   SubName: Full=Glucagon receptor {ECO:0000313|Ensembl:ENSP00000460976};
GN   Name=GCGR {ECO:0000313|Ensembl:ENSP00000460976};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460976, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460976, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000460976}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       {ECO:0000256|SAAS:SAAS00547938}.
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DR   EMBL; AC174470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L454; -.
DR   jPOST; I3L454; -.
DR   PeptideAtlas; I3L454; -.
DR   PRIDE; I3L454; -.
DR   Ensembl; ENST00000570996; ENSP00000460976; ENSG00000215644.
DR   UCSC; uc010wux.3; human.
DR   EuPathDB; HostDB:ENSG00000215644.9; -.
DR   HGNC; HGNC:4192; GCGR.
DR   OpenTargets; ENSG00000215644; -.
DR   GeneTree; ENSGT00940000157969; -.
DR   OMA; ENIQCWT; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000215644; Expressed in 69 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; I3L454; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004967; F:glucagon receptor activity; IEA:InterPro.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 4.10.1240.10; -; 1.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR036445; GPCR_2_extracell_dom_sf.
DR   InterPro; IPR001879; GPCR_2_extracellular_dom.
DR   InterPro; IPR003290; GPCR_2_GLP1/glucagon_rcpt.
DR   InterPro; IPR003291; GPCR_2_glucagon_rcpt.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF02793; HRM; 1.
DR   PRINTS; PR01353; GLUCAGNFAMLY.
DR   PRINTS; PR01354; GLUCAGONR.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00008; HormR; 1.
DR   SUPFAM; SSF111418; SSF111418; 1.
DR   PROSITE; PS00649; G_PROTEIN_RECEP_F2_1; 1.
DR   PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   G-protein coupled receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Membrane {ECO:0000256|SAAS:SAAS00501090, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:I3L454};
KW   Receptor {ECO:0000256|SAAS:SAAS00978998};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transducer {ECO:0000256|SAAS:SAAS00978998};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00501090,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    523       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003675263.
FT   TRANSMEM    147    166       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    250    274       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    335    356       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       42    125       G_PROTEIN_RECEP_F2_3.
FT                                {ECO:0000259|PROSITE:PS50227}.
FT   DOMAIN      141    422       G_PROTEIN_RECEP_F2_4.
FT                                {ECO:0000259|PROSITE:PS50261}.
SQ   SEQUENCE   523 AA;  57782 MW;  34A3332DA9D1CE85 CRC64;
     MPPCQPQRPL LLLLLLLACQ PQVPSAQVMD FLFEKWKLYG DQCHHNLSLL PPPTELVCNR
     TFDKYSCWPD TPANTTANIS CPWYLPWHHK VQHRFVFKRC GPDGQWVRGP RGQPWRDASQ
     CQMDGEEIEV QKEVAKMYSS FQVMYTVGYS LSLGALLLAL AILGGLSKLH CTRNAIHANL
     FASFVLKASS VLVIDGLLRT RYSQKIGDDL SVSTWLSDGV SPPRRPQAGG WVGSQAGGHV
     AALTLHLYQA VAGCRVAAVF MQYGIVANYC WLLVEGLYLH NLLGLATLPE RSFFSLYLGI
     GWGAPMLFVV PWAVVKCLFE NVQCWTSNDN MGFWWILRFP VFLAILINFF IFVRIVQLLV
     AKLRARQMHH TDYKFRLAKS TLTLIPLLGV HEVVFAFVTD EHAQGTLRSA KLFFDLFLSS
     FQVPARPPAP PPGAQCATPD HPVSPGPAGG CPLLLPQQGG AVGAAAALAP LAPGQSAMGG
     AEHQQPQGLI FARPRPSQQG AAVWEGWWQP GFICGDPLGW WPP
//