ID   I3L3M4_HUMAN            Unreviewed;        83 AA.
AC   I3L3M4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   13-FEB-2019, entry version 50.
DE   RecName: Full=Claudin {ECO:0000256|RuleBase:RU060637};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460571, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460571, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000460571}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- FUNCTION: Plays a major role in tight junction-specific
CC       obliteration of the intercellular space, through calcium-
CC       independent cell-adhesion activity.
CC       {ECO:0000256|RuleBase:RU060637}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|SAAS:SAAS00567644}; Multi-pass membrane protein
CC       {ECO:0000256|SAAS:SAAS00567644}.
CC   -!- SIMILARITY: Belongs to the claudin family.
CC       {ECO:0000256|RuleBase:RU060637, ECO:0000256|SAAS:SAAS00567656}.
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DR   EMBL; AC003688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L3M4; -.
DR   SMR; I3L3M4; -.
DR   STRING; 9606.ENSP00000460571; -.
DR   BioMuta; ENSG00000262302; -.
DR   jPOST; I3L3M4; -.
DR   MaxQB; I3L3M4; -.
DR   PaxDb; I3L3M4; -.
DR   PeptideAtlas; I3L3M4; -.
DR   PRIDE; I3L3M4; -.
DR   Ensembl; ENST00000577138; ENSP00000460571; ENSG00000262302.
DR   UCSC; uc060alh.1; human.
DR   EuPathDB; HostDB:ENSG00000262302.1; -.
DR   GeneCards; ENSG00000262302; -.
DR   GeneTree; ENSGT00940000160672; -.
DR   InParanoid; I3L3M4; -.
DR   OMA; FESIWEG; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000262302; Expressed in 75 organ(s), highest expression level in mucosa of transverse colon.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-UniRule.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR006187; Claudin.
DR   InterPro; IPR017974; Claudin_CS.
DR   InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR   PANTHER; PTHR12002; PTHR12002; 1.
DR   Pfam; PF00822; PMP22_Claudin; 1.
DR   PROSITE; PS01346; CLAUDIN; 1.
PE   3: Inferred from homology;
KW   Cell junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Cell membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455877, ECO:0000256|SAAS:SAAS00463381};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Tight junction {ECO:0000256|RuleBase:RU060637,
KW   ECO:0000256|SAAS:SAAS00455883};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00463381};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00463381}.
FT   SIGNAL        1     24       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        25     83       Claudin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003674547.
SQ   SEQUENCE   83 AA;  8835 MW;  9401303025BA676E CRC64;
     MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG
     MMSCKMYDSV LALSGNSVPN CSI
//