ID   I3L3D7_HUMAN            Unreviewed;       236 AA.
AC   I3L3D7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 47.
DE   SubName: Full=Serine protease 33 {ECO:0000313|Ensembl:ENSP00000460368};
DE   Flags: Fragment;
GN   Name=PRSS33 {ECO:0000313|Ensembl:ENSP00000460368};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460368, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460368, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X.,
RA   Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A.,
RA   Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.,
RA   Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L.,
RA   Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A.,
RA   Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D.,
RA   Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J.,
RA   Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I.,
RA   Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W.,
RA   Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A.,
RA   Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S.,
RA   Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L.,
RA   Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A.,
RA   Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L.,
RA   Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N.,
RA   Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M.,
RA   Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L.,
RA   Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D.,
RA   Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P.,
RA   Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M.,
RA   Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000460368}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
CC       {ECO:0000256|SAAS:SAAS00559343}.
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DR   EMBL; AC092117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L3D7; -.
DR   SMR; I3L3D7; -.
DR   jPOST; I3L3D7; -.
DR   PeptideAtlas; I3L3D7; -.
DR   PRIDE; I3L3D7; -.
DR   Ensembl; ENST00000571674; ENSP00000460368; ENSG00000103355.
DR   UCSC; uc059pqk.1; human.
DR   EuPathDB; HostDB:ENSG00000103355.12; -.
DR   HGNC; HGNC:30405; PRSS33.
DR   OpenTargets; ENSG00000103355; -.
DR   eggNOG; KOG3627; Eukaryota.
DR   eggNOG; COG5640; LUCA.
DR   GeneTree; ENSGT00940000162519; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   Bgee; ENSG00000103355; Expressed in 48 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; I3L3D7; baseline and differential.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR   CDD; cd00190; Tryp_SPc; 1.
DR   InterPro; IPR009003; Peptidase_S1_PA.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR001254; Trypsin_dom.
DR   InterPro; IPR018114; TRYPSIN_HIS.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   SUPFAM; SSF50494; SSF50494; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|SAAS:SAAS00037407};
KW   Proteomics identification {ECO:0000213|MaxQB:I3L3D7,
KW   ECO:0000213|PeptideAtlas:I3L3D7};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19    236       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003675453.
FT   DOMAIN       26    236       Peptidase S1.
FT                                {ECO:0000259|PROSITE:PS50240}.
FT   NON_TER     236    236       {ECO:0000313|Ensembl:ENSP00000460368}.
SQ   SEQUENCE   236 AA;  25399 MW;  9332AB9B50432CFB CRC64;
     MRGVSCLQVL LLLVLACGQP RMSSRIVGGR DGRDGEWPWQ ASIQHRGAHV CGGSLIAPQW
     VLTAAHCFPR RALPAEYRVR LGALRLGSTS PRTLSVPVRR VLLPPDYSED GARGDLALLQ
     LRRPVPLSAR VQPVCLPVPG ARPPPGTPCR VTGWGSLRPG VPLPEWRPLQ GVRVPLLDSR
     TCDGLYHVGA DVPQAERIVL PGSLCAGYPQ GHKDACQVCT QPPQPPESPP CAQHPP
//