ID   I3L375_HUMAN            Unreviewed;       276 AA.
AC   I3L375;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   05-DEC-2018, entry version 47.
DE   SubName: Full=Carbonic anhydrase-related protein 10 {ECO:0000313|Ensembl:ENSP00000460238};
DE   Flags: Fragment;
GN   Name=CA10 {ECO:0000313|Ensembl:ENSP00000460238};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000460238, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000460238, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000460238}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01134}.
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DR   EMBL; AC002090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC004108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC005883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC006083; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC016473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877658; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF456289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF511488; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L375; -.
DR   PeptideAtlas; I3L375; -.
DR   PRIDE; I3L375; -.
DR   Ensembl; ENST00000575181; ENSP00000460238; ENSG00000154975.
DR   UCSC; uc060hpm.1; human.
DR   EuPathDB; HostDB:ENSG00000154975.13; -.
DR   HGNC; HGNC:1369; CA10.
DR   OpenTargets; ENSG00000154975; -.
DR   eggNOG; KOG0382; Eukaryota.
DR   eggNOG; COG3338; LUCA.
DR   GeneTree; ENSGT00940000155223; -.
DR   ChiTaRS; CA10; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000154975; Expressed in 111 organ(s), highest expression level in cerebellar hemisphere.
DR   ExpressionAtlas; I3L375; baseline and differential.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   Gene3D; 3.10.200.10; -; 1.
DR   InterPro; IPR018423; CA10.
DR   InterPro; IPR001148; CA_dom.
DR   InterPro; IPR036398; CA_dom_sf.
DR   InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR   PANTHER; PTHR18952; PTHR18952; 1.
DR   PANTHER; PTHR18952:SF91; PTHR18952:SF91; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   SMART; SM01057; Carb_anhydrase; 1.
DR   SUPFAM; SSF51069; SSF51069; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:I3L375};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    276       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003674539.
FT   DOMAIN       31    276       Alpha-carbonic anhydrase.
FT                                {ECO:0000259|PROSITE:PS51144}.
FT   NON_TER     276    276       {ECO:0000313|Ensembl:ENSP00000460238}.
SQ   SEQUENCE   276 AA;  31358 MW;  625AA6735BDA5D42 CRC64;
     MEIVWEVLFL LQANFIVCIS AQQNSPKIHE GWWAYKEVVQ GSFVPVPSFW GLVNSAWNLC
     SVGKRQSPVN IETSHMIFDP FLTPLRINTG GRKVSGTMYN TGRHVSLRLD KEHLVNISGG
     PMTYSHRLEE IRLHFGSEDS QGSEHLLNGQ AFSGEVQLIH YNHELYTNVT EAAKSPNGLV
     VVSIFIKVSD SSNPFLNRML NRDTITRITY KNDAYLLQGL NIEELYPETS SFITYDGSMT
     IPPCYETASW IIMNKPVYIT RMQMHSLRLL SQNQPS
//