ID   I3L2N6_HUMAN            Unreviewed;       147 AA.
AC   I3L2N6;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Retinoid-inducible serine carboxypeptidase {ECO:0000313|Ensembl:ENSP00000459807};
GN   Name=SCPEP1 {ECO:0000313|Ensembl:ENSP00000459807};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000459807, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000459807, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000459807}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
RN   [4] {ECO:0000213|PubMed:25944712}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25944712;
RA   Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M.,
RA   Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT   "N-terminome analysis of the human mitochondrial proteome.";
RL   Proteomics 15:2519-2524(2015).
RN   [5] {ECO:0000313|Ensembl:ENSP00000487541}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase S10 family.
CC       {ECO:0000256|SAAS:SAAS01094158}.
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DR   EMBL; AC004584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC007114; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EPD; I3L2N6; -.
DR   jPOST; I3L2N6; -.
DR   MaxQB; I3L2N6; -.
DR   PeptideAtlas; I3L2N6; -.
DR   PRIDE; I3L2N6; -.
DR   Ensembl; ENST00000572591; ENSP00000459807; ENSG00000121064.
DR   Ensembl; ENST00000631024; ENSP00000487541; ENSG00000121064.
DR   UCSC; uc060htg.1; human.
DR   EuPathDB; HostDB:ENSG00000121064.12; -.
DR   HGNC; HGNC:29507; SCPEP1.
DR   OpenTargets; ENSG00000121064; -.
DR   GeneTree; ENSGT00940000156193; -.
DR   ChiTaRS; SCPEP1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000121064; Expressed in 225 organ(s), highest expression level in right adrenal gland.
DR   ExpressionAtlas; I3L2N6; baseline and differential.
DR   GO; GO:0004185; F:serine-type carboxypeptidase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001563; Peptidase_S10.
DR   PANTHER; PTHR11802; PTHR11802; 1.
DR   Pfam; PF00450; Peptidase_S10; 1.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:I3L2N6,
KW   ECO:0000213|MaxQB:I3L2N6, ECO:0000213|PeptideAtlas:I3L2N6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     26       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        27    147       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014098402.
SQ   SEQUENCE   147 AA;  16519 MW;  ADB737B9F969C42A CRC64;
     MELALRRSPV PRWLLLLPLL LGLNAGAVID WPTEEGKEVW DYVTVRKDAY MFWWLYYATN
     SCKNFSELPL VMWLQGGPGG SSTGFGNFEE IGPFSEGPSS ATLRGLPWVI PGSPLLIRCS
     PGDLTCTACL FSKTKVWQRC LRLQSKY
//