ID   GFY_HUMAN               Reviewed;         518 AA.
AC   I3L273;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 40.
DE   RecName: Full=Golgi-associated olfactory signaling regulator;
DE   AltName: Full=Protein Goofy;
DE   Flags: Precursor;
GN   Name=GFY;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- FUNCTION: Required for proper function of the olfactory system.
CC       May be involved in establishing the acuity of olfactory sensory
CC       signaling (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
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DR   EMBL; AC010619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS58672.1; -.
DR   RefSeq; NP_001182185.1; NM_001195256.1.
DR   RefSeq; XP_011524601.1; XM_011526299.2.
DR   UniGene; Hs.553831; -.
DR   ProteinModelPortal; I3L273; -.
DR   SMR; I3L273; -.
DR   iPTMnet; I3L273; -.
DR   PhosphoSitePlus; I3L273; -.
DR   BioMuta; GFY; -.
DR   jPOST; I3L273; -.
DR   MaxQB; I3L273; -.
DR   PaxDb; I3L273; -.
DR   PRIDE; I3L273; -.
DR   ProteomicsDB; 46861; -.
DR   Ensembl; ENST00000576655; ENSP00000459439; ENSG00000261949.
DR   Ensembl; ENST00000610896; ENSP00000478493; ENSG00000261949.
DR   GeneID; 100507003; -.
DR   KEGG; hsa:100507003; -.
DR   UCSC; uc021uxm.1; human.
DR   CTD; 100507003; -.
DR   EuPathDB; HostDB:ENSG00000261949.5; -.
DR   GeneCards; GFY; -.
DR   HGNC; HGNC:44663; GFY.
DR   neXtProt; NX_I3L273; -.
DR   OpenTargets; ENSG00000261949; -.
DR   eggNOG; ENOG410JAPH; Eukaryota.
DR   eggNOG; ENOG411151P; LUCA.
DR   GeneTree; ENSGT00730000111841; -.
DR   InParanoid; I3L273; -.
DR   OMA; CLFFAGT; -.
DR   OrthoDB; 795288at2759; -.
DR   GenomeRNAi; 100507003; -.
DR   PRO; PR:I3L273; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000261949; Expressed in 13 organ(s), highest expression level in cerebellar hemisphere.
DR   GO; GO:0030173; C:integral component of Golgi membrane; ISS:UniProtKB.
DR   GO; GO:1905515; P:non-motile cilium assembly; IEA:Ensembl.
DR   GO; GO:0097499; P:protein localization to non-motile cilium; IEA:Ensembl.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Complete proteome; Glycoprotein; Golgi apparatus; Membrane; Olfaction;
KW   Reference proteome; Sensory transduction; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     19       {ECO:0000255}.
FT   CHAIN        20    518       Golgi-associated olfactory signaling
FT                                regulator.
FT                                /FTId=PRO_0000424823.
FT   TOPO_DOM     20    409       Extracellular. {ECO:0000255}.
FT   TRANSMEM    410    430       Helical. {ECO:0000255}.
FT   TOPO_DOM    431    518       Cytoplasmic. {ECO:0000255}.
FT   COMPBIAS     59    367       Pro-rich.
FT   COMPBIAS    483    502       Pro-rich.
FT   CARBOHYD    124    124       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    156    156       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    188    188       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    220    220       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    268    268       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
SQ   SEQUENCE   518 AA;  56104 MW;  5D292F2EEF388453 CRC64;
     MKSFSRILFL VFLLAGLRSK AAPSAPLPLG CGFPDMAHPS ETSPLKGASE NSKRDRLNPE
     FPGTPYPEPS KLPHTVSLET FPLDFTEPLN PDLRETPHPE SPETPKADSL TTSISESLDM
     PKTNLSKMAH PESSETPTPG PTEMPHPGSP ETPKPNFSKT SRPEFPETPN TDLMQTTPQE
     SPEILQLNAT EVSQAELPET SNTNPTKTPD PKSPEKHDLN STETPNSEFL QALHPDPSKT
     PHPESHVTHN PSPTEISQTE FPTTYYQNAT DVPRTSDPQI STSLYPETPV PFKDDATALN
     ELSLNPKPGT PAAIQPDSPK LPTSDSPGMV ELKAPQNSGP KESNVPPPSA RIAGPPALPG
     RPSQLAPATL RAPQRHSRGE GVNTIIVVER VKETGVTLVG RPRGAAGGAL CLFFAGTALL
     IGIFVLLWCL YRRAARQRPF AHHRLPDDGD EPVLHLDAPK DPYDLYFYAP DTWVPSHIAT
     KQPPPTPPLP PKLPPPPRGG RPQRLEALSP ATLPNNFV
//