ID   I3L1U4_HUMAN            Unreviewed;       114 AA.
AC   I3L1U4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   16-JAN-2019, entry version 46.
DE   SubName: Full=Pigment epithelium-derived factor {ECO:0000313|Ensembl:ENSP00000459107};
GN   Name=SERPINF1 {ECO:0000313|Ensembl:ENSP00000459107};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000459107, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000459107, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000459107}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|SAAS:SAAS00596534}.
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DR   EMBL; AC130343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC130689; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L1U4; -.
DR   jPOST; I3L1U4; -.
DR   MaxQB; I3L1U4; -.
DR   PeptideAtlas; I3L1U4; -.
DR   PRIDE; I3L1U4; -.
DR   Ensembl; ENST00000573770; ENSP00000459107; ENSG00000132386.
DR   UCSC; uc059zje.1; human.
DR   EuPathDB; HostDB:ENSG00000132386.10; -.
DR   HGNC; HGNC:8824; SERPINF1.
DR   OpenTargets; ENSG00000132386; -.
DR   eggNOG; KOG2392; Eukaryota.
DR   eggNOG; COG4826; LUCA.
DR   GeneTree; ENSGT00940000158112; -.
DR   ChiTaRS; SERPINF1; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000132386; Expressed in 226 organ(s), highest expression level in pigmented layer of retina.
DR   ExpressionAtlas; I3L1U4; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   PANTHER; PTHR11461; PTHR11461; 1.
DR   Pfam; PF00079; Serpin; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:I3L1U4,
KW   ECO:0000213|PeptideAtlas:I3L1U4};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    114       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003675252.
FT   DOMAIN       57     96       SERPIN. {ECO:0000259|Pfam:PF00079}.
SQ   SEQUENCE   114 AA;  12026 MW;  4E51BEAA66B8E5AB CRC64;
     MQALVLLLCI GALLGHSSCQ NPASPPEEGS PDPDSTGALV EEEDPFFKVP VNKLAAAVSN
     FGYDLYRVRS STSPTTNVLL SPLSVATALS ALSLGLMPLT YFRKISKDEN SLAT
//