ID I3L1J2_HUMAN Unreviewed; 406 AA. AC I3L1J2; DT 11-JUL-2012, integrated into UniProtKB/TrEMBL. DT 11-JUL-2012, sequence version 1. DT 16-JAN-2019, entry version 50. DE SubName: Full=Cadherin-5 {ECO:0000313|Ensembl:ENSP00000458878}; GN Name=CDH5 {ECO:0000313|Ensembl:ENSP00000458878}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458878, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000458878, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., RA Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., RA Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., RA Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., RA Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., RA Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., RA Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., RA Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., RA Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., RA Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., RA Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., RA Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., RA Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., RA Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., RA Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., RA Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., RA Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., RA Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., RA Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., RA Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., RA Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., RA Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [2] {ECO:0000313|Ensembl:ENSP00000458878} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAY-2012) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane CC {ECO:0000256|SAAS:SAAS01075634}; Single-pass type I membrane CC protein {ECO:0000256|SAAS:SAAS01075634}. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC132186; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; I3L1J2; -. DR jPOST; I3L1J2; -. DR MaxQB; I3L1J2; -. DR PeptideAtlas; I3L1J2; -. DR PRIDE; I3L1J2; -. DR Ensembl; ENST00000563425; ENSP00000458878; ENSG00000179776. DR UCSC; uc002eon.2; human. DR EuPathDB; HostDB:ENSG00000179776.17; -. DR HGNC; HGNC:1764; CDH5. DR OpenTargets; ENSG00000179776; -. DR eggNOG; KOG3594; Eukaryota. DR eggNOG; ENOG410XQHI; LUCA. DR GeneTree; ENSGT00940000160587; -. DR ChiTaRS; CDH5; human. DR Proteomes; UP000005640; Chromosome 16. DR Bgee; ENSG00000179776; Expressed in 212 organ(s), highest expression level in placenta. DR ExpressionAtlas; I3L1J2; baseline and differential. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0001955; P:blood vessel maturation; IEA:InterPro. DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro. DR InterPro; IPR039808; Cadherin. DR InterPro; IPR002126; Cadherin-like_dom. DR InterPro; IPR015919; Cadherin-like_sf. DR InterPro; IPR020894; Cadherin_CS. DR InterPro; IPR030052; CDH5. DR PANTHER; PTHR24027; PTHR24027; 1. DR PANTHER; PTHR24027:SF89; PTHR24027:SF89; 1. DR Pfam; PF00028; Cadherin; 3. DR PRINTS; PR00205; CADHERIN. DR SMART; SM00112; CA; 3. DR SUPFAM; SSF49313; SSF49313; 3. DR PROSITE; PS00232; CADHERIN_1; 1. PE 1: Evidence at protein level; KW Calcium {ECO:0000256|SAAS:SAAS00020193}; KW Cell adhesion {ECO:0000256|SAAS:SAAS01075623}; KW Cell membrane {ECO:0000256|SAAS:SAAS01075618}; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Membrane {ECO:0000256|SAAS:SAAS00616217, KW ECO:0000256|SAAS:SAAS01075618}; KW Metal-binding {ECO:0000256|SAAS:SAAS01075609}; KW Proteomics identification {ECO:0000213|MaxQB:I3L1J2, KW ECO:0000213|PeptideAtlas:I3L1J2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Repeat {ECO:0000256|SAAS:SAAS00436611}; KW Signal {ECO:0000256|SAM:SignalP}; KW Transmembrane {ECO:0000256|SAAS:SAAS00616217}; KW Transmembrane helix {ECO:0000256|SAAS:SAAS00616217}. FT SIGNAL 1 28 {ECO:0000256|SAM:SignalP}. FT CHAIN 29 406 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003675241. FT DOMAIN 68 149 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 173 256 CA. {ECO:0000259|SMART:SM00112}. FT DOMAIN 280 371 CA. {ECO:0000259|SMART:SM00112}. SQ SEQUENCE 406 AA; 45414 MW; 98DDAC2C4FD99A45 CRC64; MQRLMMLLAT SGACLGLLAV AAVAAAGANP AQRDTHSLLP THRRQKRDWI WNQMHIDEEK NTSLPHHVGK IKSSVSRKNA KYLLKGEYVG KVFRVDAETG DVFAIERLDR ENISEYHLTA VIVDKDTGEN LETPSSFTIK VHDVNDNWPV FTHRLFNASV PESSAVGTSV ISVTAVDADD PTVGDHASVM YQILKGKEYF AIDNSGRIIT ITKSLDREKQ ARYEIVVEAR DAQGLRGDSG TATVLVTLQD INDNFPFFTQ TKYTFVVPED TRVGTSVGSL FVEDPDEPQN RMTKYSILRG DYQDAFTIET NPAHNEGIIK PMKPLDYEYI QQYSFIVEAT DPTIDLRYMS PPAGNRAQVI INITDVDEPP IFQQPFYHFQ LKENQKKPLI GTVLAMDPDA ARHSIG //