ID   I3L0M1_HUMAN            Unreviewed;       181 AA.
AC   I3L0M1;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Sex hormone-binding globulin {ECO:0000313|Ensembl:ENSP00000458199};
GN   Name=SHBG {ECO:0000313|Ensembl:ENSP00000458199};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000458199, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000458199, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R.,
RA   Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N.,
RA   Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B.,
RA   Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J.,
RA   Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E.,
RA   Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J.,
RA   Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C.,
RA   Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in
RT   the human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000458199}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAY-2012) to UniProtKB.
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DR   EMBL; AC007421; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; I3L0M1; -.
DR   PeptideAtlas; I3L0M1; -.
DR   PRIDE; I3L0M1; -.
DR   Ensembl; ENST00000570353; ENSP00000458199; ENSG00000129214.
DR   UCSC; uc060auf.1; human.
DR   EuPathDB; HostDB:ENSG00000129214.14; -.
DR   HGNC; HGNC:10839; SHBG.
DR   OpenTargets; ENSG00000129214; -.
DR   eggNOG; ENOG410IKW6; Eukaryota.
DR   eggNOG; ENOG410YKMT; LUCA.
DR   GeneTree; ENSGT00940000154035; -.
DR   ChiTaRS; SHBG; human.
DR   Proteomes; UP000005640; Chromosome 17.
DR   Bgee; ENSG00000129214; Expressed in 92 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; I3L0M1; baseline and differential.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   Pfam; PF00054; Laminin_G_1; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:I3L0M1,
KW   ECO:0000213|PeptideAtlas:I3L0M1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     29       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        30    181       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003675415.
FT   DOMAIN       75    121       LAM_G_DOMAIN. {ECO:0000259|Pfam:PF00054}.
SQ   SEQUENCE   181 AA;  19808 MW;  7D5FCF665B9F2958 CRC64;
     MESRGPLATS RLLLLLLLLL LRHTRQGWAL RPVLPTQSAH DPPAVHLSNG PGQEPIAVMT
     FDLTKITKTS SSFEVRTWDP EGVIFYGDTN PKDDWFMLGL RDGRPEIQLH NHWAQLTVGA
     APETGLWAPD QQTPSHHEDC AWGAALPRFQ PSVAAGSCPG WLPAPGFLAG QTGRDLSICP
     H
//