ID   H9KVB3_HUMAN            Unreviewed;      2913 AA.
AC   H9KVB3;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 2.
DT   16-JAN-2019, entry version 55.
DE   SubName: Full=Otogelin {ECO:0000313|Ensembl:ENSP00000382329};
GN   Name=OTOG {ECO:0000313|Ensembl:ENSP00000382329};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000382329, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000382329, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000382329}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00567783}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00039}.
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DR   EMBL; AC124799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KC877393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001278992.1; NM_001292063.1.
DR   UniGene; Hs.688380; -.
DR   ProteinModelPortal; H9KVB3; -.
DR   SMR; H9KVB3; -.
DR   PRIDE; H9KVB3; -.
DR   Ensembl; ENST00000399397; ENSP00000382329; ENSG00000188162.
DR   GeneID; 340990; -.
DR   UCSC; uc057znr.1; human.
DR   CTD; 340990; -.
DR   EuPathDB; HostDB:ENSG00000188162.10; -.
DR   HGNC; HGNC:8516; OTOG.
DR   OpenTargets; ENSG00000188162; -.
DR   eggNOG; ENOG410IR87; Eukaryota.
DR   eggNOG; ENOG410Y3IZ; LUCA.
DR   GeneTree; ENSGT00940000157490; -.
DR   OrthoDB; 12226at2759; -.
DR   ChiTaRS; OTOG; human.
DR   GenomeRNAi; 340990; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000188162; Expressed in 23 organ(s), highest expression level in pituitary gland.
DR   ExpressionAtlas; H9KVB3; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0008344; P:adult locomotory behavior; IEA:InterPro.
DR   GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR   GO; GO:0007605; P:sensory perception of sound; IEA:InterPro.
DR   InterPro; IPR007934; AbfB_ABD.
DR   InterPro; IPR036195; AbfB_ABD_sf.
DR   InterPro; IPR006207; Cys_knot_C.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR030105; Otogelin.
DR   InterPro; IPR036084; Ser_inhib-like_sf.
DR   InterPro; IPR002919; TIL_dom.
DR   InterPro; IPR014853; Unchr_dom_Cys-rich.
DR   InterPro; IPR001007; VWF_dom.
DR   InterPro; IPR001846; VWF_type-D.
DR   PANTHER; PTHR11339:SF228; PTHR11339:SF228; 1.
DR   Pfam; PF05270; AbfB; 1.
DR   Pfam; PF08742; C8; 4.
DR   Pfam; PF01826; TIL; 1.
DR   Pfam; PF00094; VWD; 4.
DR   SMART; SM00832; C8; 4.
DR   SMART; SM00041; CT; 1.
DR   SMART; SM00215; VWC_out; 2.
DR   SMART; SM00216; VWD; 4.
DR   SUPFAM; SSF110221; SSF110221; 1.
DR   SUPFAM; SSF57567; SSF57567; 4.
DR   PROSITE; PS01225; CTCK_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
DR   PROSITE; PS51233; VWFD; 4.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00039,
KW   ECO:0000256|SAAS:SAAS00509702};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H9KVB3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00509699};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26   2913       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003622148.
FT   DOMAIN       90    127       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      139    341       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      501    715       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN      973   1175       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     2099   2311       VWFD. {ECO:0000259|PROSITE:PS51233}.
FT   DOMAIN     2828   2913       CTCK. {ECO:0000259|PROSITE:PS01225}.
FT   DISULFID   2842   2891       {ECO:0000256|PROSITE-ProRule:PRU00039}.
SQ   SEQUENCE   2913 AA;  313393 MW;  D164130542CF81D0 CRC64;
     MGVLASALCW LLCVWLPWGE QAAESLRVQR LAAAPVLWGS AEPQPEPAGQ PSSSHQEATL
     AMGDKATVVG GQQAEAPDSV AMSSWERRLH RAKCAPSYLF SCFNGGECVH PAFCDCRRFN
     ATGPRCQMVY NAGPERDSIC RAWGQHHVET FDGLYYYLSG KGSYTLVGRH EPEGQSFSIQ
     VHNDPQCGSS PYTCSRAVSL FFVGEQEIHL AKEVTHGGMR VQLPHVMGSA RLQQLAGYVI
     VRHQSAFTLA WDGASAVYIK MSPELLGWTH GLCGNNNADP KDDLVTSSGK LTDDVVEFVH
     SWQEQAPNQP PGPTTSSLPR PPCLQQNPGT MQGVYEQCEA LLRPPFDACH AYVSPLPFTA
     SCTSDLCQSM GDVATWCRAL AEYARACAQA GRPLQGWRTQ LRQCTVHCKE KAFTYNECIA
     CCPASCHPRA SCVDSEIACV DGCYCPNGLI FEDGGCVAPA ECPCEFHGTL YPPGSVVKED
     CNTCTCTSGK WECSTAVCPA ECSVTGDIHF TTFDGRRYTF PATCQYILAK SRSSGTFTVT
     LQNAPCGLNQ DGACVQSVSV ILHQDPRRQV TLTQAGDVLL FDQYKIIPPY TDDAFEIRRL
     SSVFLRVRTN VGVRVLYDRE GLRLYLQVDQ RWVEDTVGLC GTFNGNTQDD FLSPVGVPES
     TPQLFGNSWK TLSACSPLVS GSPLDPCDVH LQAASYSVQA CSVLTGEMFA PCSAFLSPVP
     YFEQCRRDAC RCGQPCLCAT LAHYAHLCRR HGLPVDFRAR LPACALSCEA SKEYSPCVAP
     CGRTCQDLAS PEACGVDGGD DLSRDECVEG CACPPDTYLD TQADLCVPRN QCSCHFQGVD
     YPPGDSDIPS LGHCHCKDGV MSCDSRAPAA ACPAGQVFVN CSDLHTDLEL SRERTCEQQL
     LNLSVSARGP CLSGCACPQG LLRHGDACFL PEECPCTWKG KEYFPGDQVM SPCHTCVCQR
     GSFQCTLHPC ASTCTAYGDR HYRTFDGLPF DFVGACKVHL VKSTSDVSFS VIVENVNCYS
     SGMICRKFIS INVGNSLIVF DDDSGNPSPE SFLDDKQEVH TWRVGFFTLV HFPQEHITLL
     WDQRTTVHVQ AGPQWQGQLA GLCGNFDLKT INEMRTPENL ELTNPQEFGS SWAAVECPDT
     LDPRDMCVLN PLREPFAKKE CSILLSEVFE ICHPVVDVTW FYSNCLTDTC GCSQGGDCEC
     FCASVSAYAH QCCQHGVAVD WRTPRLCPYD CDFFNKVLGK GPYQLSSLAA GGALVGMKAV
     GDDIVLVRTE DVAPADIVSF LLTAALYKAK AHDPDVVSLE AADRPNFFLH VTANGSLELA
     KWQGRDTFQQ HASFLLHRGT RQAGLVALES LAKPSSFLYV SGAVLALRLY EHTEVFRRGT
     LFRLLDAKPS GAAYPICEWR YDACASPCFQ TCRDPRAASC RDVPRVEGCV PVCPTPQVLD
     EVTQRCVYLE DCVEPAVWVP TEALGNETLP PSQGLPTPSD EEPQLSQESP RTPTHRPALT
     PAAPLTTALN PPVTATEEPV VSPGPTQTTL QQPLELTASQ LPAGPTESPA SKGVTASLLA
     IPHTPESSSL PVALQTPTPG MVSGAMETTR VTVIFAGSPN ITVSSRSPPA PRFPLMTKAV
     TVRGHGSLPV RTTPPQPSLT ASPSSRPVAS PGAISRSPTS SGSHKAVLTP AVTKVISRTG
     VPQPTQAQSA SSPSTPLTVA GTAAEQVPVS PLATRSLEIV LSTEKGEAGH SQPMGSPASP
     QPHPLPSAPP RPAQHTTMAT RSPALPPETP AAASLSTATD GLAATPFMSL ESTRPSQLLS
     GLPPDTSLPL AKVGTSAPVA TPGPKASVIT TPLQPQATTL PAQTLSPVLP FTPAAMTQAH
     PPTHIAPPAA GTAPGLLLGA TLPTSGVLPV AEGTASMVSV VPRKSTTGKV AILSKQVSLP
     TSMYGSAEGG PTELTPATSH PLTPLVAEPE GAQAGTALPV PTSYALSRVS ARTAPQDSML
     VLLPQLAEAH GTSAGPHLAA EPVDEATTEP SGRSAPALSI VEGLAEALAT TTEANTSTTC
     VPIAEQDCVR HICLEGQLIR VNQSQHCPQG AAPPRCGILG LAVRVGGDRC CPLWECACRC
     SIFPDLSFVT FDGSHVALFK EAIYILSQSP DEMLTVHVLD CKSANLGHLN WPPFCLVMLN
     MTHLAHQVTI DRFNRKVTVD LQPVWPPVSR YGFRIEDTGH MYMILTPSDI QIQWLHSSGL
     MIVEASKTSK AQGHGLCGIC DGDAANDLTL KDGSVVGGAE DPAPFLDSWQ VPSSLTSVGQ
     TRFRPDSCAT TDCSPCLRMV SNRTFSACHR FVPPESFCEL WIRDTKYVQQ PCVALTVYVA
     MCHKFHVCIE WRRSDYCPFL CSSDSTYQAC VTACEPPKTC QDGILGPLDP EHCQVLGEGC
     VCSEGTILHR RHSALCIPEA KCACTDSMGV PRALGETWNS SLSGCCQHQC QAPDTIVPVD
     LGCPSPRPES CLRFGEVALL LPTKDPCCLG TVCVCNQTLC EGLAPTCRPG HRLLTHFQED
     SCCPSYSCEC DPDLCEAELV PSCRQDQILI TGRLGDSCCT SYFCACGDCP DSIPECQEGE
     ALTVHRNTTE LCCPLYQCVC ENFRCPQVQC GLGTALVEVW SPDRCCPYKS CECDCDTIPV
     PRCHLWEKSQ LDEEFMHSVE NVCGCAKYEC VKAPVCLSRE LGVMQPGQTV VELSADGVCH
     TSRCTTVLDP LTNFYQINTT SVLCDIHCEA NQEYEHPRDL AACCGSCRNV SCLFTFPNGT
     TSLFLPGASW IADCARHHCS STPLGAVLVR SPISCPPLNE TECAKVGGSV VPSLEGCCRT
     CKEDGRSCKK VTIRMTIRKN ECRSSTPVNL VSCDGRCPSA SIYNYNINTY ARFCKCCREV
     GLQRRSVQLF CATNATWVPY TVQEPTDCAC QWS
//