ID   H9KV48_HUMAN            Unreviewed;       463 AA.
AC   H9KV48;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   16-JAN-2019, entry version 52.
DE   SubName: Full=Plasma protease C1 inhibitor {ECO:0000313|Ensembl:ENSP00000341861};
GN   Name=SERPING1 {ECO:0000313|Ensembl:ENSP00000341861};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000341861, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000341861, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000341861}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
RN   [3] {ECO:0000213|PubMed:24275569}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
RA   Wang L., Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human
RT   liver phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- SIMILARITY: Belongs to the serpin family.
CC       {ECO:0000256|RuleBase:RU000411, ECO:0000256|SAAS:SAAS00596534}.
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DR   EMBL; AP000662; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AP002893; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H9KV48; -.
DR   SMR; H9KV48; -.
DR   jPOST; H9KV48; -.
DR   PeptideAtlas; H9KV48; -.
DR   PRIDE; H9KV48; -.
DR   Ensembl; ENST00000340687; ENSP00000341861; ENSG00000149131.
DR   UCSC; uc058bmw.1; human.
DR   EuPathDB; HostDB:ENSG00000149131.15; -.
DR   HGNC; HGNC:1228; SERPING1.
DR   OpenTargets; ENSG00000149131; -.
DR   GeneTree; ENSGT00940000159681; -.
DR   ChiTaRS; SERPING1; human.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000149131; Expressed in 232 organ(s), highest expression level in right lobe of liver.
DR   ExpressionAtlas; H9KV48; baseline and differential.
DR   GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0045916; P:negative regulation of complement activation; IEA:InterPro.
DR   GO; GO:0030193; P:regulation of blood coagulation; IEA:InterPro.
DR   InterPro; IPR015553; C1-inh.
DR   InterPro; IPR023795; Serpin_CS.
DR   InterPro; IPR023796; Serpin_dom.
DR   InterPro; IPR000215; Serpin_fam.
DR   InterPro; IPR036186; Serpin_sf.
DR   PANTHER; PTHR11461; PTHR11461; 2.
DR   PANTHER; PTHR11461:SF159; PTHR11461:SF159; 2.
DR   Pfam; PF00079; Serpin; 2.
DR   SMART; SM00093; SERPIN; 1.
DR   SUPFAM; SSF56574; SSF56574; 1.
DR   PROSITE; PS00284; SERPIN; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H9KV48,
KW   ECO:0000213|PeptideAtlas:H9KV48};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    463       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003620918.
FT   DOMAIN      151    461       SERPIN. {ECO:0000259|SMART:SM00093}.
SQ   SEQUENCE   463 AA;  50989 MW;  273D647CEA7F19B6 CRC64;
     MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI SKMLFVEPIL
     EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI QPTQPTTQLP TDSPTQPTTG
     SFCPGPVTLC SDLESHSTEA VLGDALVDFS LKLYHAFSAM KKVETNMAFS PFSIASLLTQ
     VLLGAGENTK TNLESILSYP KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS
     RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK
     TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKAIMEKLE MSKFQPTLLT
     LPRIKVTTSQ DMLSIMEKLE FFDFSYDLNL CGLTEDPDLQ VSAMQHQTVL ELTETGVEAA
     AASAISVART LLVFEVQQPF LFVLWDQQHK FPVFMGRVYD PRA
//