ID   H9KV29_HUMAN            Unreviewed;       180 AA.
AC   H9KV29;
DT   16-MAY-2012, integrated into UniProtKB/TrEMBL.
DT   16-MAY-2012, sequence version 1.
DT   16-JAN-2019, entry version 48.
DE   SubName: Full=Signal-regulatory protein beta-1 {ECO:0000313|Ensembl:ENSP00000262929};
GN   Name=SIRPB1 {ECO:0000313|Ensembl:ENSP00000262929};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000262929, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000262929, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11780052; DOI=10.1038/414865a;
RA   Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA   Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M.,
RA   Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J.,
RA   Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M.,
RA   Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R.,
RA   Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M.,
RA   Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA   Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA   Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA   Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA   Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA   Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA   Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA   Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA   Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA   Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H.,
RA   Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E.,
RA   Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A.,
RA   Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M.,
RA   Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A.,
RA   Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S.,
RA   Rogers J.;
RT   "The DNA sequence and comparative analysis of human chromosome 20.";
RL   Nature 414:865-871(2001).
RN   [2] {ECO:0000313|Ensembl:ENSP00000262929}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2012) to UniProtKB.
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DR   EMBL; AL049634; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL138804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL592544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001317568.1; NM_001330639.1.
DR   UniGene; Hs.664861; -.
DR   ProteinModelPortal; H9KV29; -.
DR   jPOST; H9KV29; -.
DR   MaxQB; H9KV29; -.
DR   PeptideAtlas; H9KV29; -.
DR   PRIDE; H9KV29; -.
DR   Ensembl; ENST00000262929; ENSP00000262929; ENSG00000101307.
DR   GeneID; 10326; -.
DR   UCSC; uc061uzd.1; human.
DR   CTD; 10326; -.
DR   EuPathDB; HostDB:ENSG00000101307.15; -.
DR   HGNC; HGNC:15928; SIRPB1.
DR   OpenTargets; ENSG00000101307; -.
DR   eggNOG; ENOG410J9BU; Eukaryota.
DR   eggNOG; ENOG410ZT4H; LUCA.
DR   GeneTree; ENSGT00940000163660; -.
DR   OrthoDB; 904196at2759; -.
DR   GenomeRNAi; 10326; -.
DR   Proteomes; UP000005640; Chromosome 20.
DR   Bgee; ENSG00000101307; Expressed in 113 organ(s), highest expression level in blood.
DR   ExpressionAtlas; H9KV29; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H9KV29};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     28       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        29    180       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003622143.
FT   TRANSMEM    153    176       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       13    119       Ig-like. {ECO:0000259|PROSITE:PS50835}.
SQ   SEQUENCE   180 AA;  19219 MW;  8C7918FB9F185A79 CRC64;
     MPVPASWPHP PCPFLLLTLL LGLTGVAGED ELQVIQPEKS VSVAAGESAT LRCAMTSLIP
     VGPIMWFRGA GAGRELIYNQ KEGHFPRVTT VSELTKRNNL DFSISISNIT PADAGTYYCV
     KFRKGSPDDV EFKSGAGTEL SVREAALAPT APLLVALLLG PKLLLVVGVS AIYICWKQKA
//