ID   H7C5J8_HUMAN            Unreviewed;       222 AA.
AC   H7C5J8;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2016, sequence version 8.
DT   05-DEC-2018, entry version 45.
DE   SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 8 {ECO:0000313|Ensembl:ENSP00000420099};
DE   Flags: Fragment;
GN   Name=ENTPD8 {ECO:0000313|Ensembl:ENSP00000420099};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000420099, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000420099, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15164053; DOI=10.1038/nature02465;
RA   Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E.,
RA   Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S.,
RA   Babbage A.K., Babbage S., Bagguley C.L., Bailey J., Banerjee R.,
RA   Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W.,
RA   Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G.,
RA   Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M.,
RA   Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W.,
RA   Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A.,
RA   Frankland J.A., French L., Fricker D.G., Garner P., Garnett J.,
RA   Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA   Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA   Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA   Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA   Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA   Kimberley A.M., King A., Knights A., Laird G.K., Langford C.,
RA   Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M.,
RA   Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S.,
RA   McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J.,
RA   Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R.,
RA   Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M.,
RA   Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M.,
RA   Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A.,
RA   Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W.,
RA   Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.,
RA   Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S.,
RA   Rogers J., Dunham I.;
RT   "DNA sequence and analysis of human chromosome 9.";
RL   Nature 429:369-374(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000420099}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC       {ECO:0000256|SAAS:SAAS00594473}.
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DR   EMBL; BX322799; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C5J8; -.
DR   PRIDE; H7C5J8; -.
DR   Ensembl; ENST00000493135; ENSP00000420099; ENSG00000188833.
DR   UCSC; uc064xll.1; human.
DR   EuPathDB; HostDB:ENSG00000188833.9; -.
DR   HGNC; HGNC:24860; ENTPD8.
DR   OpenTargets; ENSG00000188833; -.
DR   eggNOG; KOG1386; Eukaryota.
DR   eggNOG; COG5371; LUCA.
DR   GeneTree; ENSGT00940000153151; -.
DR   Proteomes; UP000005640; Chromosome 9.
DR   Bgee; ENSG00000188833; Expressed in 55 organ(s), highest expression level in mucosa of transverse colon.
DR   ExpressionAtlas; H7C5J8; baseline and differential.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR000407; GDA1_CD39_NTPase.
DR   PANTHER; PTHR11782; PTHR11782; 1.
DR   Pfam; PF01150; GDA1_CD39; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Hydrolase {ECO:0000256|SAAS:SAAS00136878};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    222       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5008415189.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000420099}.
FT   NON_TER     222    222       {ECO:0000313|Ensembl:ENSP00000420099}.
SQ   SEQUENCE   222 AA;  23472 MW;  94A4833EDC850A93 CRC64;
     LGASGVSGLT ALILLLVEAT SVLLPTDIKF GIVFDAGSSH TSLFLYQWLA NKENGTGVVS
     QALACQVEGP GISSYTSNAA QAGESLQGCL EEALVLIPEA QHRKTPTFLG ATAGMRLLSS
     HPGPGPVSRG LLGCRAPGRA GRRCLWLDHC QLRLGDAGQV LLHWRMDPAS GGDAGGCPGH
     GRGLHPDHVR AWGPHLGQEH PGRFSPLRLR LQRLHSQLPV LW
//