ID   H7C557_HUMAN            Unreviewed;      1323 AA.
AC   H7C557;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   16-JAN-2019, entry version 49.
DE   SubName: Full=Multiple epidermal growth factor-like domains protein 6 {ECO:0000313|Ensembl:ENSP00000419033};
GN   Name=MEGF6 {ECO:0000313|Ensembl:ENSP00000419033};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000419033, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000419033, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
RA   Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.,
RA   Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
RA   McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
RA   Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I., Aubin K.,
RA   Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
RA   Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
RA   Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
RA   Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
RA   Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
RA   Hammond S., Harrison E.S., Hart E., Haugen E., Heath P.D., Holmes S.,
RA   Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J.,
RA   James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K.,
RA   Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G.,
RA   Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J.,
RA   Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L.,
RA   Matthews N.S., McLaren S., Milne S., Mistry S., Moore M.J.,
RA   Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A.,
RA   Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K.,
RA   Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G.,
RA   Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S.,
RA   Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N.,
RA   Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S.,
RA   Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L.,
RA   Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.,
RA   Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T.,
RA   Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R., Banerjee R.,
RA   Bryant S.P., Burford D.C., Burrill W.D., Clegg S.M., Dhami P.,
RA   Dovey O., Faulkner L.M., Gribble S.M., Langford C.F., Pandian R.D.,
RA   Porter K.M., Prigmore E.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000419033}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AL512413; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL513320; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C557; -.
DR   jPOST; H7C557; -.
DR   PeptideAtlas; H7C557; -.
DR   PRIDE; H7C557; -.
DR   Ensembl; ENST00000485002; ENSP00000419033; ENSG00000162591.
DR   UCSC; uc057bpq.1; human.
DR   EuPathDB; HostDB:ENSG00000162591.15; -.
DR   HGNC; HGNC:3232; MEGF6.
DR   OpenTargets; ENSG00000162591; -.
DR   eggNOG; KOG1218; Eukaryota.
DR   eggNOG; ENOG410XQWV; LUCA.
DR   GeneTree; ENSGT00940000156971; -.
DR   ChiTaRS; MEGF6; human.
DR   Proteomes; UP000005640; Chromosome 1.
DR   Bgee; ENSG00000162591; Expressed in 127 organ(s), highest expression level in descending thoracic aorta.
DR   ExpressionAtlas; H7C557; baseline and differential.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR011489; EMI_domain.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF07645; EGF_CA; 1.
DR   Pfam; PF12661; hEGF; 5.
DR   Pfam; PF00053; Laminin_EGF; 2.
DR   SMART; SM00181; EGF; 23.
DR   SMART; SM00179; EGF_CA; 8.
DR   SMART; SM00180; EGF_Lam; 13.
DR   SUPFAM; SSF57184; SSF57184; 3.
DR   PROSITE; PS00010; ASX_HYDROXYL; 3.
DR   PROSITE; PS00022; EGF_1; 11.
DR   PROSITE; PS01186; EGF_2; 4.
DR   PROSITE; PS50026; EGF_3; 15.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS51041; EMI; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00601599};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
KW   ECO:0000256|SAAS:SAAS00032677};
KW   Proteomics identification {ECO:0000213|MaxQB:H7C557,
KW   ECO:0000213|PeptideAtlas:H7C557};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Repeat {ECO:0000256|SAAS:SAAS00594563};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     30       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        31   1323       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003609239.
FT   DOMAIN       44    125       EMI. {ECO:0000259|PROSITE:PS51041}.
FT   DOMAIN      168    208       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      245    291       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      292    332       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      419    459       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      523    559       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      567    602       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      610    645       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      743    777       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      790    821       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      829    864       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      872    908       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN      916    951       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1002   1037       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1045   1080       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DOMAIN     1088   1123       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   DISULFID    549    558       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    592    601       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    635    644       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    767    776       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    811    820       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    854    863       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    898    907       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    941    950       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   1027   1036       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   1070   1079       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID   1113   1122       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1323 AA;  138401 MW;  812611BCB5C73341 CRC64;
     MSFLEEARAA GRAVVLALVL LLLPAVPVGA SVPPRPLLPL QPGMPHVCAE QELTLVGRRQ
     PCVQALSHTV PVWKAGCGWQ AWCVGHERRT VYYMGYRQVY TTEARTVLRC CRGWMQQPDE
     EGCLSDVGEC ANANGGCAGR CRDTVGGFYC RWPPPSHQLQ GDGETCQDVD ECRTHNGGCQ
     HRCVNTPGSY LCECKPGFRL HTDSRTCLAI NSCALGNGGC QHHCVQLTIT RHRCQCRPGF
     QLQEDGRHCV RRSPCANRNG SCMHRCQVVR GLARCECHVG YQLAADGKAC EDVDECAAGL
     AQCAHGCLNT QGSFKCVCHA GYELGADGRQ CYRIEMEIVN SCEANNGGCS HGCSHTSAGP
     LCTCPRGYEL DTDQRTCIDV DDCADSPCCQ QVCTNNPGGY ECGCYAGYRL SADGCGCEDV
     DECASSRGGC EHHCTNLAGS FQCSCEAGYR LHEDRRGCSP LEEPMVDLDG ELPFVRPLPH
     IAVLQDELPQ LFQDDDVGAD EEEAELRGEH TLTEKFVCLD DSFGHDCSLT CDDCRNGGTC
     LLGLDGCDCP EGWTGLICNE TCPPDTFGKN CSFSCSCQNG GTCDSVTGAC RCPPGVSGTN
     CEDGCPKGYY GKHCRKKCNC ANRGRCHRLY GACLCDPGLY GRFCHLTCPP WAFGPGCSEE
     CQCVQPHTQS CDKRDGSCSC KAGFRGERCQ AECELGYFGP GCWQACTCPV GVACDSVSGE
     CGKRCPAGFQ GEDCGQECPV GTFGVNCSSS CSCGGAPCHG VTGQCRCPPG RTGEDCEADC
     PEGRWGLGCQ EICPACQHAA RCDPETGACL CLPGFVGSRC QDVCPAGWYG PSCQTRCSCA
     NDGHCHPATG HCSCAPGWTG FSCQRACDTG HWGPDCSHPC NCSAGHGSCD AISGLCLCEA
     GYVGPRCEQQ CPQGHFGPGC EQRCQCQHGA ACDHVSGACT CPAGWRGTFC EHACPAGFFG
     LDCRSACNCT AGAACDAVNG SCLCPAGRRG PRCAETCPAH TYGHNCSQAC ACFNGASCDP
     VHGQCHCAPG WMGPSCLQAC PAGLYGDNCR HSCLCQNGGT CDPVSGHCAC PEGWAGLACE
     KECLPRDVRA GCRHSGGCLN GGLCDPHTGR CLCPAGWTGD KCQSPCAKGT FGPHCEGRCA
     CRWGGPCHLA TGACLCPPGW RGAPGVRMPA CGAGLERPVP SAAAARLALP ATTSLGPAAV
     PLASLAPAAS RPAHPAALGR TVRRCASVPV RTRPATLPPG PAHVLLATTA PAASNDVRPG
     GMGQAVNSCV GVSTGAPVMR PRGPAAAPLG SSGRTATSPV RRAASAPTAP TCVGVGRGRP
     ATL
//