ID   H7C545_HUMAN            Unreviewed;       190 AA.
AC   H7C545;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Roundabout homolog 1 {ECO:0000313|Ensembl:ENSP00000418946};
DE   Flags: Fragment;
GN   Name=ROBO1 {ECO:0000313|Ensembl:ENSP00000418946};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000418946, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000418946, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000213|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0000313|Ensembl:ENSP00000418946}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC016946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC055731; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106718; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC106720; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC108719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC117479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC119035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC123565; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC131008; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C545; -.
DR   EPD; H7C545; -.
DR   MaxQB; H7C545; -.
DR   PeptideAtlas; H7C545; -.
DR   PRIDE; H7C545; -.
DR   Ensembl; ENST00000472273; ENSP00000418946; ENSG00000169855.
DR   UCSC; uc062lqm.1; human.
DR   EuPathDB; HostDB:ENSG00000169855.19; -.
DR   HGNC; HGNC:10249; ROBO1.
DR   OpenTargets; ENSG00000169855; -.
DR   eggNOG; KOG4222; Eukaryota.
DR   eggNOG; ENOG410XPQS; LUCA.
DR   GeneTree; ENSGT00940000154477; -.
DR   ChiTaRS; ROBO1; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000169855; Expressed in 223 organ(s), highest expression level in forebrain.
DR   ExpressionAtlas; H7C545; baseline and differential.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   GO; GO:0007507; P:heart development; IEA:InterPro.
DR   GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR   InterPro; IPR032986; Robo1.
DR   PANTHER; PTHR44096:SF1; PTHR44096:SF1; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H7C545,
KW   ECO:0000213|PeptideAtlas:H7C545};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    190       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608478.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000418946}.
FT   NON_TER     190    190       {ECO:0000313|Ensembl:ENSP00000418946}.
SQ   SEQUENCE   190 AA;  21116 MW;  3402E2F6386A88A8 CRC64;
     XFQNSDLLFI LLVSRFGMSD HNKEPGMQLD DRLLLTTFQW QAYHLDFHLC LNYRANDTVP
     PTIPYNQSYD QNTGGSYNSS DRGSSTSGSQ GHKKGARTPK VPKQGGMNWA DLLPPPPAHP
     PPHSNSEEYN ISVDESYDQE MPCPVPPARM YLQQDELEEE EDERGPTPPV RGAASSPAAV
     SYSHQSTATL
//