ID   H7C4H1_HUMAN            Unreviewed;       224 AA.
AC   H7C4H1;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 42.
DE   SubName: Full=Phospholipase A1 member A {ECO:0000313|Ensembl:ENSP00000417295};
DE   Flags: Fragment;
GN   Name=PLA1A {ECO:0000313|Ensembl:ENSP00000417295};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000417295, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000417295, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000417295}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}.
CC   -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase
CC       family. {ECO:0000256|RuleBase:RU004262,
CC       ECO:0000256|SAAS:SAAS00591292}.
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DR   EMBL; AC073352; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C4H1; -.
DR   SMR; H7C4H1; -.
DR   PeptideAtlas; H7C4H1; -.
DR   PRIDE; H7C4H1; -.
DR   Ensembl; ENST00000475963; ENSP00000417295; ENSG00000144837.
DR   UCSC; uc062mvd.1; human.
DR   EuPathDB; HostDB:ENSG00000144837.8; -.
DR   HGNC; HGNC:17661; PLA1A.
DR   OpenTargets; ENSG00000144837; -.
DR   eggNOG; ENOG410IJ4N; Eukaryota.
DR   eggNOG; ENOG4110U23; LUCA.
DR   GeneTree; ENSGT00940000159279; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000144837; Expressed in 145 organ(s), highest expression level in corpus epididymis.
DR   ExpressionAtlas; H7C4H1; baseline and differential.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0052689; F:carboxylic ester hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; -; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013818; Lipase/vitellogenin.
DR   InterPro; IPR000734; TAG_lipase.
DR   PANTHER; PTHR11610; PTHR11610; 1.
DR   Pfam; PF00151; Lipase; 1.
DR   PRINTS; PR00821; TAGLIPASE.
DR   SUPFAM; SSF53474; SSF53474; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H7C4H1,
KW   ECO:0000213|PeptideAtlas:H7C4H1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Secreted {ECO:0000256|SAAS:SAAS00439306};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    224       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608334.
FT   DOMAIN        1    202       Lipase. {ECO:0000259|Pfam:PF00151}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000417295}.
SQ   SEQUENCE   224 AA;  24093 MW;  32DED503746DC5E2 CRC64;
     NVIKLSLEIS LFLNKLLVLG VSESSIHIIG VSLGAHVGGM VGQLFGGQLG QITGLDPAGP
     EYTRASVEER LDAGDALFVE AIHTDTDNLG IRIPVGHVDY FVNGGQDQPG CPTFFYAGYS
     YLICDHMRAV HLYISALENS CPLMAFPCAS YKAFLAGRCL DCFNPFLLSC PRIGLVEQGG
     VKIEPLPKEV KVYLLTTSSA PYCNAFQLLT VAPNHGISLK LGCW
//