ID   H7C479_HUMAN            Unreviewed;       225 AA.
AC   H7C479;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 43.
DE   SubName: Full=Vesicle-trafficking protein SEC22c {ECO:0000313|Ensembl:ENSP00000415969};
DE   Flags: Fragment;
GN   Name=SEC22C {ECO:0000313|Ensembl:ENSP00000415969};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000415969, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000415969, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000415969}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC092047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C479; -.
DR   Ensembl; ENST00000451653; ENSP00000415969; ENSG00000093183.
DR   UCSC; uc062ipp.1; human.
DR   EuPathDB; HostDB:ENSG00000093183.13; -.
DR   HGNC; HGNC:16828; SEC22C.
DR   OpenTargets; ENSG00000093183; -.
DR   eggNOG; KOG0862; Eukaryota.
DR   eggNOG; COG5143; LUCA.
DR   GeneTree; ENSGT00940000159338; -.
DR   ChiTaRS; SEC22C; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000093183; Expressed in 202 organ(s), highest expression level in epithelium of mammary gland.
DR   ExpressionAtlas; H7C479; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     19       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        20    225       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003609223.
FT   TRANSMEM    106    126       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    164       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    171    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    194    212       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000415969}.
SQ   SEQUENCE   225 AA;  25555 MW;  7B11C618A9BFB885 CRC64;
     XAAMAFCFLE TLWWEFTASY DTTCIGLASR PYAFLEFDSI IQKVKWHFNY VSSSQMECSL
     EKIQEELKLQ PPAVLTLEDT DVANGVMNGH TPMHLEPAPN FRMEPVTALG ILSLILNIMC
     AALNLIRGVH LAEHSLQVAH EEIGNILAFL VPFVACIFQC YLYLFYSPAR TMKVVLMLLF
     ICLGNMYLHG LRNLWQILFH IGVAFLSSYQ ILTRQLQEKQ SDCGV
//