ID   H7C3J0_HUMAN            Unreviewed;       399 AA.
AC   H7C3J0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   16-JAN-2019, entry version 34.
DE   SubName: Full=All-trans-retinol 13,14-reductase {ECO:0000313|Ensembl:ENSP00000412166};
DE   Flags: Fragment;
GN   Name=RETSAT {ECO:0000313|Ensembl:ENSP00000412166};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000412166, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000412166, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000213|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
RA   Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000412166}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC062037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C3J0; -.
DR   jPOST; H7C3J0; -.
DR   MaxQB; H7C3J0; -.
DR   PeptideAtlas; H7C3J0; -.
DR   PRIDE; H7C3J0; -.
DR   Ensembl; ENST00000449375; ENSP00000412166; ENSG00000042445.
DR   UCSC; uc061lfg.1; human.
DR   EuPathDB; HostDB:ENSG00000042445.13; -.
DR   HGNC; HGNC:25991; RETSAT.
DR   OpenTargets; ENSG00000042445; -.
DR   eggNOG; KOG4254; Eukaryota.
DR   eggNOG; COG1233; LUCA.
DR   GeneTree; ENSGT00390000017613; -.
DR   ChiTaRS; RETSAT; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000042445; Expressed in 222 organ(s), highest expression level in adipose tissue.
DR   ExpressionAtlas; H7C3J0; baseline and differential.
DR   Gene3D; 3.50.50.60; -; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|EPD:H7C3J0,
KW   ECO:0000213|MaxQB:H7C3J0, ECO:0000213|PeptideAtlas:H7C3J0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     21       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        22    399       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608711.
FT   COILED      378    398       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000412166}.
SQ   SEQUENCE   399 AA;  43818 MW;  B7CF2A8EA64B520E CRC64;
     XPLVLLLAVL LLAVLCKVYL GLFSGSSPNP FSEDVKRPPA PLVTDKEARK KVLKQGVTPN
     HSAFSMHALL VNHYMKGGFY PRGGSSEIAF HTIPVIQRAG GAVLTKATVQ SVLLDSAGKA
     CGVSVKKGHE LVNIYCPIVV SNAGLFNTYE HLLPGNARCL PGVKQQLGTV RPGLGMTSVF
     ICLRGTKEDL HLPSTNYYVY YDTDMDQAME RYVSMPREEA AEHIPLLFFA FPSAKDPTWE
     DRFPGRSTMI MLIPTAYEWF EEWQAELKGK RGSDYETFKN SFVEASMSVV LKLFPQLEGK
     VESVTAGSPL TNQFYLAAPR GACYGADHDL GRLHPCVMAS LRAQSPIPNL YLTGQDIFTC
     GLVGALQGAL LCSSAILKRN LYSDLKNLDS RIRAQKKKN
//