ID   H7C1B9_HUMAN            Unreviewed;        95 AA.
AC   H7C1B9;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   05-DEC-2018, entry version 35.
DE   SubName: Full=Sodium- and chloride-dependent taurine transporter {ECO:0000313|Ensembl:ENSP00000399522};
DE   Flags: Fragment;
GN   Name=SLC6A6 {ECO:0000313|Ensembl:ENSP00000399522};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000399522, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000399522, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000399522}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
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DR   EMBL; AC090941; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC090952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC093496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEKP01055341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7C1B9; -.
DR   MaxQB; H7C1B9; -.
DR   PeptideAtlas; H7C1B9; -.
DR   Ensembl; ENST00000452151; ENSP00000399522; ENSG00000131389.
DR   UCSC; uc062gzx.1; human.
DR   EuPathDB; HostDB:ENSG00000131389.16; -.
DR   HGNC; HGNC:11052; SLC6A6.
DR   OpenTargets; ENSG00000131389; -.
DR   eggNOG; KOG3659; Eukaryota.
DR   eggNOG; COG0733; LUCA.
DR   GeneTree; ENSGT00940000154583; -.
DR   ChiTaRS; SLC6A6; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000131389; Expressed in 203 organ(s), highest expression level in right ovary.
DR   ExpressionAtlas; H7C1B9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro.
DR   InterPro; IPR000175; Na/ntran_symport.
DR   InterPro; IPR037272; SNS_sf.
DR   PANTHER; PTHR11616; PTHR11616; 2.
DR   Pfam; PF00209; SNF; 1.
DR   SUPFAM; SSF161070; SSF161070; 1.
DR   PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAAS:SAAS00943634, ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:H7C1B9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Symport {ECO:0000256|SAAS:SAAS00943603};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00943634,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00943634,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00943603}.
FT   SIGNAL        1     25       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        26     95       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608281.
FT   TRANSMEM     51     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000399522}.
FT   NON_TER      95     95       {ECO:0000313|Ensembl:ENSP00000399522}.
SQ   SEQUENCE   95 AA;  10888 MW;  FCFC2C8DAFC52E10 CRC64;
     XTMMPLPTFW SILFFIMLLL LGLDSQGCFI FSLVKYVPLT YNKTYVYPNW AIGLGWSLAL
     SSMLCVPLVI VIRLCQTEGP FLVRVKYLLT PREPN
//