ID   H7BZM3_HUMAN            Unreviewed;       222 AA.
AC   H7BZM3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   12-SEP-2018, entry version 34.
DE   SubName: Full=N-glycosylase/DNA lyase {ECO:0000313|Ensembl:ENSP00000390337};
DE   Flags: Fragment;
GN   Name=OGG1 {ECO:0000313|Ensembl:ENSP00000390337};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390337, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000390337, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
RA   Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
RA   Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
RA   Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
RA   Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
RA   Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Wei S.,
RA   Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
RA   Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
RA   Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
RA   Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
RA   Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
RA   Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
RA   Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
RA   Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Palmeiri A.,
RA   Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J.,
RA   Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
RA   Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
RA   Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000390337}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; AC022382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; H7BZM3; -.
DR   STRING; 9606.ENSP00000306561; -.
DR   EPD; H7BZM3; -.
DR   MaxQB; H7BZM3; -.
DR   PaxDb; H7BZM3; -.
DR   PeptideAtlas; H7BZM3; -.
DR   PRIDE; H7BZM3; -.
DR   Ensembl; ENST00000441094; ENSP00000390337; ENSG00000114026.
DR   UCSC; uc062glu.1; human.
DR   EuPathDB; HostDB:ENSG00000114026.21; -.
DR   HGNC; HGNC:8125; OGG1.
DR   OpenTargets; ENSG00000114026; -.
DR   eggNOG; KOG2875; Eukaryota.
DR   eggNOG; COG0122; LUCA.
DR   GeneTree; ENSGT00640000091554; -.
DR   ChiTaRS; OGG1; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000114026; Expressed in 222 organ(s), highest expression level in adult mammalian kidney.
DR   ExpressionAtlas; H7BZM3; baseline and differential.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0006284; P:base-excision repair; IEA:InterPro.
DR   CDD; cd00056; ENDO3c; 1.
DR   Gene3D; 1.10.1670.10; -; 1.
DR   InterPro; IPR011257; DNA_glycosylase.
DR   InterPro; IPR003265; HhH-GPD_domain.
DR   InterPro; IPR023170; HTH_base_excis_C.
DR   Pfam; PF00730; HhH-GPD; 1.
DR   SMART; SM00478; ENDO3c; 1.
DR   SUPFAM; SSF48150; SSF48150; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Proteomics identification {ECO:0000213|MaxQB:H7BZM3,
KW   ECO:0000213|PeptideAtlas:H7BZM3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL        1     27       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        28    222       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003608635.
FT   DOMAIN       44    214       ENDO3c. {ECO:0000259|SMART:SM00478}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000390337}.
SQ   SEQUENCE   222 AA;  24529 MW;  722FA1BF4C1A4CF3 CRC64;
     XPCGPPSRAL ALSCAWTWFC LLDNLSGVRL LRQDPIECLF SFICSSNNNI ARITGMVERL
     CQAFGPRLIQ LDDVTYHGFP SLQALAGPEV EAHLRKLGLG YRARYVSASA RAILEEQGGL
     AWLQQLRESS YEEAHKALCI LPGVGTKVAD CICLMALDKP QAVPVDVHMW HIAQRDYSWH
     PTTSQAKGPS PQTNKELGNF FRSLWGPYAG WAQAVSVPRC PP
//