ID H7BZL2_HUMAN Unreviewed; 206 AA. AC H7BZL2; DT 18-APR-2012, integrated into UniProtKB/TrEMBL. DT 18-APR-2012, sequence version 1. DT 16-JAN-2019, entry version 43. DE SubName: Full=3-hydroxyisobutyrate dehydrogenase, mitochondrial {ECO:0000313|Ensembl:ENSP00000390205}; DE Flags: Fragment; GN Name=HIBADH {ECO:0000313|Ensembl:ENSP00000390205}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000390205, ECO:0000313|Proteomes:UP000005640}; RN [1] {ECO:0000313|Ensembl:ENSP00000390205, ECO:0000313|Proteomes:UP000005640} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=12853948; DOI=10.1038/nature01782; RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., RA Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., RA Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., RA Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., RA Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., RA Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., RA Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., RA Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., RA Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., RA Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., RA Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., RA Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., RA Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., RA Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., RA Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., RA Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., RA Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., RA Waterston R.H., Wilson R.K.; RT "The DNA sequence of human chromosome 7."; RL Nature 424:157-164(2003). RN [2] {ECO:0000213|PubMed:21269460} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., RA Burckstummer T., Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [3] {ECO:0000313|Ensembl:ENSP00000390205} RP IDENTIFICATION. RG Ensembl; RL Submitted (FEB-2012) to UniProtKB. RN [4] {ECO:0000213|PubMed:24275569} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014; RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., RA Wang L., Ye M., Zou H.; RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human RT liver phosphoproteome."; RL J. Proteomics 96:253-262(2014). RN [5] {ECO:0000213|PubMed:25944712} RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=25944712; RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., RA Ayoub D., Lane L., Bairoch A., Van Dorsselaer A., Carapito C.; RT "N-terminome analysis of the human mitochondrial proteome."; RL Proteomics 15:2519-2524(2015). CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC ----------------------------------------------------------------------- DR EMBL; AC005091; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; AC007130; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; KF458419; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR ProteinModelPortal; H7BZL2; -. DR EPD; H7BZL2; -. DR jPOST; H7BZL2; -. DR MaxQB; H7BZL2; -. DR PeptideAtlas; H7BZL2; -. DR PRIDE; H7BZL2; -. DR Ensembl; ENST00000425715; ENSP00000390205; ENSG00000106049. DR UCSC; uc064cij.1; human. DR EuPathDB; HostDB:ENSG00000106049.8; -. DR HGNC; HGNC:4907; HIBADH. DR OpenTargets; ENSG00000106049; -. DR eggNOG; KOG0409; Eukaryota. DR eggNOG; COG2084; LUCA. DR GeneTree; ENSGT00940000155255; -. DR ChiTaRS; HIBADH; human. DR Proteomes; UP000005640; Chromosome 7. DR Bgee; ENSG00000106049; Expressed in 201 organ(s), highest expression level in kidney epithelium. DR ExpressionAtlas; H7BZL2; baseline and differential. DR GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:InterPro. DR GO; GO:0051287; F:NAD binding; IEA:InterPro. DR GO; GO:0050661; F:NADP binding; IEA:InterPro. DR Gene3D; 1.10.1040.10; -; 1. DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf. DR InterPro; IPR013328; 6PGD_dom2. DR InterPro; IPR006115; 6PGDH_NADP-bd. DR InterPro; IPR011548; HIBADH. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR InterPro; IPR029154; NADP-bd. DR Pfam; PF14833; NAD_binding_11; 1. DR Pfam; PF03446; NAD_binding_2; 1. DR SUPFAM; SSF48179; SSF48179; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR TIGRFAMs; TIGR01692; HIBADH; 1. PE 1: Evidence at protein level; KW Complete proteome {ECO:0000313|Proteomes:UP000005640}; KW Proteomics identification {ECO:0000213|EPD:H7BZL2, KW ECO:0000213|MaxQB:H7BZL2, ECO:0000213|PeptideAtlas:H7BZL2}; KW Reference proteome {ECO:0000313|Proteomes:UP000005640}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 35 {ECO:0000256|SAM:SignalP}. FT CHAIN 36 206 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5003608430. FT DOMAIN 28 143 NAD_binding_2. FT {ECO:0000259|Pfam:PF03446}. FT DOMAIN 146 200 NAD_binding_11. FT {ECO:0000259|Pfam:PF14833}. FT NON_TER 1 1 {ECO:0000313|Ensembl:ENSP00000390205}. FT NON_TER 206 206 {ECO:0000313|Ensembl:ENSP00000390205}. SQ SEQUENCE 206 AA; 21403 MW; FCDBD76EB7AA1316 CRC64; XELPHTLKLP GLPLFPNKFL ISLVLLILVS SPADVAEKAD RIITMLPTSI NAIEAYSGAN GILKKVKKGS LLIDSSTIDP AVSKELAKEV EKMGAVFMDA PVSGGVGAAR SGNLTFMVGG VEDEFAAAQE LLGCMGSNVV YCGAVGTGQA AKICNNMLLA ISMIGTAEAM NLGIRLGLDP KLLAKILNMS SGRCWSSDTY NPVPGV //